Observational studyJournal of the American Heart Association2014
Resistive and pulsatile arterial hemodynamics and cardiovascular events: the Multiethnic Study of Atherosclerosis.
Observational study in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Low systemic arterial compliance is associated with increased cardiovascular morbidity and mortality in aortic valve stenosis.Heart (British Cardiac Society) · 2019Trial
- Hyperdynamic circulation distinguishes predominantly diastolic hypertension from predominantly systolic hypertension.Journal of human hypertension · 2025Article
- Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health.JACC. Advances · 2025Article
- Case Report: Intra-aortic balloon pump in a patient with refractory cardiogenic shock complicating severe aortic stenosis-enhanced hemodynamic response with low aortic compliance.Frontiers in cardiovascular medicine · 2025Article
- Adolescents and Young Adults with Type 1 Diabetes Present Changes in Arterial Compliance and Resistance and Increased Arterial Stiffness.Pediatric diabetes · 2024Observational
- Variations of arterial compliance and vascular resistance due to plaque or infarct in a single vascular territory of the middle cerebral artery.Quantitative imaging in medicine and surgery · 2023Article
- Ischemic Heart Disease and Vascular Risk Factors Are Associated With Accelerated Brain Aging.JACC. Cardiovascular imaging · 2023Article
- Estimated pulse wave velocity and incident heart failure and its subtypes: Findings from the multi-ethnic study of atherosclerosis.American heart journal plus : cardiology research and practice · 2023Article
- Living Arrangement: a Contributor to Vascular Disease in Asymptomatic African American Women.Journal of the Georgia Public Health Association · 2019Article
- Arterial properties in adults with long-lasting active juvenile idiopathic arthritis compared to healthy controls.Pediatric rheumatology online journal · 2018Article
- Hemodynamic Patterns Identified by Impedance Cardiography Predict Mortality in the General Population: The PREVENCION Study.Journal of the American Heart Association · 2018Article
- Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- Aortic flow conditions predict ejection efficiency in the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE).Cardiovascular diagnosis and therapy · 2017Article
- Pulmonary and systemic hemodynamics are associated with myocardial injury in the acute respiratory distress syndrome.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundArterial blood pressure is dependent on interactions between the heart and arteries. Resistive and pulsatile components of arterial load can be assessed by systemic vascular resistance (SVR, a microvascular property) and the ratio of stroke volume to pulse pressure (a surrogate of total arterial compliance, TAC), respectively. The relationship between arterial function and cardiovascular events in populations without cardiovascular disease is unknown. METHODS AND
resultsWe studied 4806 adults enrolled in the Multi-Ethnic Study of Atherosclerosis who were free of clinical cardiovascular disease at baseline. SVR and stroke volume/pulse pressure (SV/PP) were derived by sphygmomanometry and magnetic resonance imaging. The relationship between these measures of arterial function and incident cardiovascular events was assessed using Cox regression. With a mean follow-up of 7.5 years, cardiovascular events occurred in 358 participants (7.4%). There was no relationship between SVR and subsequent cardiovascular events. However, increased stroke volume/pulse pressure was associated with reduced event rate in unadjusted (hazard ratio=0.67, 95% CI=0.58 to 0.77, P<0.001) and analyses that adjusted for multiple confounders (HR=0.75; 95% CI=0.62 to 0.90; P<0.001).
conclusionsGreater total arterial compliance, manifest by higher stroke volume/pulse pressure is associated with a reduced incidence of subsequent CVE. In contrast, SVR was not independently associated with CVE in subjects free of overt cardiovascular disease at baseline. These findings support the concept that alternations in the large conduit vessels, rather than changes in microvascular resistance, are primarily related to incident cardiovascular disease.
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