Evidence map›Paper›PMID 25497362›Full record

Trial reportInternational psychogeriatrics2015

Predictors of change in quality of life in older adults with generalized anxiety disorder.

Srijana Shrestha, Melinda A Stanley, Nancy L Wilson, Jeffrey A Cully, Mark E Kunik, Diane M Novy, Howard M Rhoades, Amber B Amspoker

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International psychogeriatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00308724 (Treating Late-Life Generalized Anxiety Disorder), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00308724 nacompletednot on this map

Treating Late-Life Generalized Anxiety Disorder (GAD) in Primary Care

TypeinterventionalSponsorBaylor College of MedicineRan2004 to 2015Enrolled148ConditionsGeneralized Anxiety DisorderArmsCognitive Behavior Therapy, Telephone check-in
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Predicting change in quality of life from age 79 to 90 in the Lothian Birth Cohort 1921.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Srijana ShresthaVA HSR&D Houston Center for Innovations in Quality,Effectiveness and Safety,Michael E. DeBakey VA Medical Center,(MEDVAMC 152),2002 Holcombe Blvd., Houston,TX 77030,USA.
Melinda A StanleyVA HSR&D Houston Center for Innovations in Quality,Effectiveness and Safety,Michael E. DeBakey VA Medical Center,(MEDVAMC 152),2002 Holcombe Blvd., Houston,TX 77030,USA.
Nancy L WilsonVA HSR&D Houston Center for Innovations in Quality,Effectiveness and Safety,Michael E. DeBakey VA Medical Center,(MEDVAMC 152),2002 Holcombe Blvd., Houston,TX 77030,USA.
Jeffrey A CullyVA HSR&D Houston Center for Innovations in Quality,Effectiveness and Safety,Michael E. DeBakey VA Medical Center,(MEDVAMC 152),2002 Holcombe Blvd., Houston,TX 77030,USA.
Mark E KunikVA HSR&D Houston Center for Innovations in Quality,Effectiveness and Safety,Michael E. DeBakey VA Medical Center,(MEDVAMC 152),2002 Holcombe Blvd., Houston,TX 77030,USA.
Diane M NovyDepartment of Anesthesiology and Pain Medicine,The University of Texas M.D. Anderson Cancer Center,1515 Holcombe Blvd.,Unit 409,Houston,TX 77030,USA.
Howard M RhoadesHarris County Psychiatric Center,The University of Texas Health Sciences Center,P.O. Box 20249,Houston,TX 77225,USA.
Amber B AmspokerVA HSR&D Houston Center for Innovations in Quality,Effectiveness and Safety,Michael E. DeBakey VA Medical Center,(MEDVAMC 152),2002 Holcombe Blvd., Houston,TX 77030,USA.
Michael E. DeBakey VA Medical Center · USCenter for Innovation · USMental Illness Research, Education and Clinical Centers · USThe University of Texas MD Anderson Cancer Center · US

Funding

TREATMENT OF GENERALIZED ANXIETY DISORDER IN THE ELDERLYR01MH053932 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI STANLEY, MELINDA A · 1996 to 2012
$5.6M
NIMH NIH HHS R01 MH053932NIMH NIH HHS R01-MH53932
6 · The paper itself

Abstract

backgroundQuality of life (QOL) is lower in older adults with generalized anxiety disorder (GAD). QOL generally improves following cognitive-behavioral treatment for GAD. Little is known, however, about additional variables predicting changes in QOL in older adults with GAD. This study examined predictors of change in QOL among older participants in a randomized clinical trial of cognitive behavioral therapy (CBT) for GAD, relative to enhanced usual care (EUC).

methodsHierarchical multilevel mixed-model analyses were used to examine inter-individual and intra-individual factors that predicted QOL over time. Predictors were categorized into treatment, personal and clinical characteristics.

resultsQOL improved over time, and there was significant variability between participants in change in QOL. Controlling for treatment condition, baseline general self-efficacy, baseline social support, within-person variation in worry and depression and average levels of depression across different time points predicted changes in QOL.

conclusionsQOL has increasingly been used as an outcome measure in treatment outcome studies to focus on overall improvement in functioning. Attention to improvement in symptoms of depression and worry, along with psychosocial variables, such as social support and self-efficacy, may help improve QOL in older adults with GAD. This study was a secondary study of data from a randomized clinical trial (NCT00308724) registered with clinical.trials.gov.

Indexed as

Quality of LifeAgedAged, 80 and overAnxiety DisordersCognitive Behavioral TherapyDepressionFemaleHumansMaleMiddle AgedPrognosisSelf EfficacySocial SupportTreatment Outcomegeneralized anxiety disorderolder adultspredictorsquality of life

Identifiers

PMID25497362
PMCPMC4502441
OpenAlexW2129598587

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.