Evidence map›Paper›PMID 25497332›Full record

ArticleEpidemiology and psychiatric sciences2015

Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010.

F J Charlson, A J Baxter, T Dua, L Degenhardt, H A Whiteford, T Vos

Abstract read
In one paragraph

Article in Epidemiology and psychiatric sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F J CharlsonQueensland Centre for Mental Health Research,Wacol,Queensland,Australia.
A J BaxterQueensland Centre for Mental Health Research,Wacol,Queensland,Australia.
T DuaWorld Health Organization,Department of Mental Health and Substance Abuse,Geneva.
L DegenhardtUniversity of Washington, Institute for Health Metrics and Evaluation,Seattle,Washington,USA.
H A WhitefordQueensland Centre for Mental Health Research,Wacol,Queensland,Australia.
T VosUniversity of Washington, Institute for Health Metrics and Evaluation,Seattle,Washington,USA.

Funding

World Health Organization 001
6 · The paper itself

Abstract

aimsMortality-associated burden of disease estimates from the Global Burden of Disease 2010 (GBD 2010) may erroneously lead to the interpretation that premature death in people with mental, neurological and substance use disorders (MNSDs) is inconsequential when evidence shows that people with MNSDs experience a significant reduction in life expectancy. We explore differences between cause-specific and excess mortality of MNSDs estimated by GBD 2010.

methodsGBD 2010 cause-specific death estimates were produced using the International Classification of Diseases death-coding system. Excess mortality (all-cause) was estimated using natural history models. Additional mortality attributed to MNSDs as underlying causes but not captured through GBD 2010 methodology is quantified in the comparative risk assessments.

resultsIn GBD 2010, MNSDs were estimated to be directly responsible for 840 000 deaths compared with more than 13 million excess deaths using natural history models.

conclusionsNumbers of excess deaths and attributable deaths clearly demonstrate the high degree of mortality associated with these disorders. There is substantial evidence pointing to potential causal pathways for this premature mortality with evidence-based interventions available to address this mortality. The life expectancy gap between persons with MNSDs and the general population is high and should be a focus for health systems reform.

Indexed as

neuropsychiatry

Identifiers

PMID25497332
PMCPMC6998140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.