ArticleSchizophrenia research2015
Hippocampal dysfunction during declarative memory encoding in schizophrenia and effects of genetic liability.
Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.Neuroscience and biobehavioral reviews · 2019Pooled it
- Characterizing hippocampal dynamics with MEG: A systematic review and evidence-based guidelines.Human brain mapping · 2019Pooled it
- Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies.Neuropsychopharmacology reports · 2018Pooled it
- Alterations of the occipital lobe in schizophrenia.Neurosciences (Riyadh, Saudi Arabia) · 2015Pooled it
- Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.Nature. Mental health · 2025Article
- Genetic Diversity in Schizophrenia: Developmental Implications of Ultra-Rare, Protein-Truncating Mutations.Genes · 2024Review
- Blunted brain responses to neutral faces in healthy first-degree relatives of patients with schizophrenia: an image-based fMRI meta-analysis.Schizophrenia (Heidelberg, Germany) · 2024Review
- Alterations in white matter network dynamics in patients with schizophrenia and bipolar disorder.Human brain mapping · 2022Article
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- Neural Signatures of Memory Encoding in Schizophrenia Are Modulated by Antipsychotic Treatment.Neuropsychobiology · 2021Article
- Noncanonical, Dopamine-Dependent Long-Term Potentiation at Hippocampal Output Synapses in a Rodent Model of First-Episode Psychosis.Frontiers in molecular neuroscience · 2020Article
- Altered Brain Activation During Memory Retrieval Precedes and Predicts Conversion to Psychosis in Individuals at Clinical High Risk.Schizophrenia bulletin · 2019Article
- Memory and cognition in schizophrenia.Molecular psychiatry · 2019Review
- Associative Memory Impairments Are Associated With Functional Alterations Within the Memory Network in Schizophrenia Patients and Their Unaffected First-Degree Relatives: An fMRI Study.Frontiers in psychiatry · 2019Article
- Development of a selective left-hemispheric fronto-temporal network for processing syntactic complexity in language comprehension.Neuropsychologia · 2016Article
- Lasting Differential Effects on Plasticity Induced by Prenatal Stress in Dorsal and Ventral Hippocampus.Neural plasticity · 2016Review
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Authors and funding
8 authors.
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Abstract
Declarative memory (DM) impairments are reported in schizophrenia and in unaffected biological relatives of patients. However, the neural correlates of successful and unsuccessful encoding, mediated by the medial temporal lobe (MTL) memory system, and the influence of disease-related genetic liability remain under explored. This study employed an event-related functional MRI paradigm to compare activations for successfully and unsuccessfully encoded associative face-name stimuli between 26 schizophrenia patients (mean age: 33, 19m/7f), 30 controls (mean age: 29, 24m/6f), and 14 unaffected relatives of patients (mean age: 40, 5m/9f). Compared to controls or unaffected relatives, patients showed hyper-activations in ventral visual stream and temporo-parietal cortical association areas when contrasting successfully encoded events to fixation. Follow-up hippocampal regions-of-interest analysis revealed schizophrenia-related hyper-activations in the right anterior hippocampus during successful encoding; contrasting successful versus unsuccessful events produced schizophrenia-related hypo-activations in the left anterior hippocampus. Similar hippocampal hypo-activations were observed in unaffected relatives during successful versus unsuccessful encoding. Post hoc analyses of hippocampal volume showed reductions in patients, but not in unaffected relatives compared to controls. Findings suggest that DM encoding deficits are attributable to both disease-specific and genetic liability factors that impact different components of the MTL memory system. Hyper-activations in temporo-occipital and parietal regions observed only in patients suggest the influence of disease-related factors. Regional hyper- and hypo-activations attributable to successful encoding occurring in both patients and unaffected relatives suggest the influence of schizophrenia-related genetic liability factors.
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