ReviewNeuroscience and biobehavioral reviews2015
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.
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Review in Neuroscience and biobehavioral reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
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Who cites it
55 citing papers in PubMed.
- Vagus Nerve Stimulation Attenuates Cognitive Impairment in Traumatic Brain Injury via the mtDNA/cGAS-STING/NLRP3 Inflammasome Axis.Neurocritical care · 2026Article
- Cooking for disability: a pilot study on nutritional interventions for mental health support in adults with autism spectrum disorder.Frontiers in psychiatry · 2025Article
- Delayed-and-abbreviated environmental enrichment after traumatic brain injury confers neurobehavioral benefits similar to immediate-and-continuous exposure.Brain research · 2025Article
- Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation.Frontiers in molecular neuroscience · 2025Article
- Pre-operative environmental enrichment does not yield a prophylactic effect against traumatic brain injury-induced neurobehavioral deficits.Experimental neurology · 2025Article
- Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes.Frontiers in cellular neuroscience · 2025Article
- The evolving pathophysiology of TBI and the advantages of temporally-guided combination therapies.Neurochemistry international · 2024Review
- A bridge to recovery: Acute amantadine prior to environmental enrichment after brain trauma augments cognitive benefit.Experimental neurology · 2024Article
- Gamma frequency connectivity in frontostriatal networks associated with social preference is reduced with traumatic brain injury.Network neuroscience (Cambridge, Mass.) · 2024Article
- Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy.Experimental neurology · 2023Article
- Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Sustained attention performance deficits in the three-choice serial reaction time task in male and female rats after experimental brain trauma.Brain research · 2023Article
- Enriching adult male rats prior to traumatic brain injury does not attenuate neurobehavioral or histological deficits.Brain research · 2023Article
- Antipsychotic Drugs: The Antithesis to Neurorehabilitation in Models of Pre-Clinical Traumatic Brain Injury.Neurotrauma reports · 2023Article
- Article
- A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders.Communications biology · 2022Article
- Early Life Stress Preceding Mild Pediatric Traumatic Brain Injury Increases Neuroinflammation but Does Not Exacerbate Impairment of Cognitive Flexibility during Adolescence.Journal of neurotrauma · 2021Article
- Intranasally Administered L-Myc-Immortalized Human Neural Stem Cells Migrate to Primary and Distal Sites of Damage after Cortical Impact and Enhance Spatial Learning.Stem cells international · 2021Article
- Gene Expression Signature of Traumatic Brain Injury.Frontiers in genetics · 2021Article
- Preclinical neurorehabilitation with environmental enrichment confers cognitive and histological benefits in a model of pediatric asphyxial cardiac arrest.Experimental neurology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Corina O BondiPhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States.
Bridgette D SempleNeurological Surgery and the Graduate Program in Physical Medicine & Rehabilitation Science, University of California, San Francisco, San Francisco, CA, United States; Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Parkville, VIC, Australia.
Linda J Noble-HaeussleinNeurological Surgery and the Graduate Program in Physical Medicine & Rehabilitation Science, University of California, San Francisco, San Francisco, CA, United States.
Nicole D OsierSafar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; School of Nursing, University of Pittsburgh, Pittsburgh, PA, United States.
Shaun W CarlsonSafar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
C Edward DixonSafar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States; Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, United States.
Christopher C GizaPediatric Neurology and Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States; UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Anthony E KlinePhysical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States; Psychology, University of Pittsburgh, Pittsburgh, PA, United States; Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: klineae@upmc.edu.
Funding
PEDIATRIC NEUROINTENSIVE CARE AND RESUSCITATION RESEARCHT32HD040686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert S B Clark, PATRICK M KOCHANEK · 2000 to 2026
$7.1MTargeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5MUsing glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8MOptimizing Environmental Enrichment to Model Preclinical NeurorehabilitationR01NS084967 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2014 to 2025
$3.7MReconnection of Neural Networks and Cognitive Recovery after Pediatric TBIR01HD061504 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASARNOW, ROBERT F · 2010 to 2014
$2.9MTrauma to Developing Brain-Injury and Repair MechanismsR01NS050159 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOBLE, LINDA J. · 2005 to 2013
$2.8MDeterminants of vulnerability and recovery after trauma to the developing brainR01NS077767 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOBLE, LINDA J. · 2012 to 2016
$1.7MSNARE Proteins and TBIR01NS079061 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DIXON, C EDWARD · 2012 to 2016
$1.6MDopamine Signaling Mechanisms of Traumatic Brain InjuryR01NS060672 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DIXON, C EDWARD · 2009 to 2013
$1.6MEnvironmental Enrichment and Cholinergic Mechanisms after TBIR01NS060005 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2009 to 2013
$1.6MUnderstanding the Impact of Antipsychotic Drugs on Recovery After TBIR01HD069620 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2012 to 2016
$1.6MHeme Oxygenase and Spinal Cord InjuryR01NS039847 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NOBLE, LINDA J. · 2001 to 2004
$1.2MNICHD NIH HHS HD061504NICHD NIH HHS HD069620NICHD NIH HHS R01 HD061504NICHD NIH HHS R01 HD069620NICHD NIH HHS T32 HD040686NINDS NIH HHS NS027544NINDS NIH HHS NS050159NINDS NIH HHS NS060005NINDS NIH HHS NS060672NINDS NIH HHS NS077767NINDS NIH HHS NS079061NINDS NIH HHS NS084967NINDS NIH HHS R01 NS027544NINDS NIH HHS R01 NS039847NINDS NIH HHS R01 NS050159NINDS NIH HHS R01 NS060005NINDS NIH HHS R01 NS060672NINDS NIH HHS R01 NS077767NINDS NIH HHS R01 NS079061NINDS NIH HHS R01 NS084967NINR NIH HHS F31 NR014957NINR NIH HHS F31NR014957NINR NIH HHS T32 NR009759RRD VA I01 RX001127
Abstract
The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided.
Indexed as
BiologyTranslational Research, BiomedicalAnimalsBrain InjuriesDisease Models, AnimalEnvironmentHumansAttentional set-shifting test (AST)Closed head injuryConcussionControlled cortical impact (CCI)Environmental enrichment (EE)Fluid percussion (FP)NeurorehabilitationPediatricsSocial behavior
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