ArticleeLife2014
The transcription factor Pitx2 positions the embryonic axis and regulates twinning.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
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- InCURA: integrative gene clustering based on transcription factor binding sites.Nucleic acids research · 2025Article
- Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.Nature communications · 2025Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Development and functions of the area opaca of the chick embryo.Developmental biology · 2025Review
- Canonical Wnt signalling from the area opaca induces and maintains the marginal zone in pre-primitive-streak stage chick embryos.Development (Cambridge, England) · 2025Article
- Article
- Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity.Nature communications · 2024Article
- Association of Novel C319T Variant ofBioinformatics and biology insights · 2023Article
- Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates.The Malaysian journal of medical sciences : MJMS · 2022Review
- The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo.Development (Cambridge, England) · 2022Article
- 'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours.Development (Cambridge, England) · 2022Article
- Expression patterns of signalling molecules and transcription factors in the early rabbit embryo and their significance for modelling amniote axis formation.Development genes and evolution · 2021Article
- Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse.Innovation (Cambridge (Mass.)) · 2020Article
- Cellular processes driving gastrulation in the avian embryo.Mechanisms of development · 2020Review
- The extracellular matrix in development.Development (Cambridge, England) · 2020Review
- Molecular anatomy of the pre-primitive-streak chick embryo.Open biology · 2020Article
- Transcriptome analysis revealed misregulated gene expression in blastoderms of interspecific chicken and Japanese quail F1 hybrids.PloS one · 2020Article
- Article
- Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 6 countries.
Funding
Abstract
Embryonic polarity of invertebrates, amphibians and fish is specified largely by maternal determinants, which fixes cell fates early in development. In contrast, amniote embryos remain plastic and can form multiple individuals until gastrulation. How is their polarity determined? In the chick embryo, the earliest known factor is cVg1 (homologous to mammalian growth differentiation factor 1, GDF1), a transforming growth factor beta (TGFβ) signal expressed posteriorly before gastrulation. A molecular screen to find upstream regulators of cVg1 in normal embryos and in embryos manipulated to form twins now uncovers the transcription factor Pitx2 as a candidate. We show that Pitx2 is essential for axis formation, and that it acts as a direct regulator of cVg1 expression by binding to enhancers within neighbouring genes. Pitx2, Vg1/GDF1 and Nodal are also key actors in left-right asymmetry, suggesting that the same ancient polarity determination mechanism has been co-opted to different functions during evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.