ArticleBMC evolutionary biology2014
Impacts of genetic correlation on the independent evolution of body mass and skeletal size in mammals.
Article in BMC evolutionary biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Revisiting the Palimpsest: Exploring the Interaction of the Variance and Structure of Developmental Determinants of Phenotypic Covariance.Integrative and comparative biology · 2026Article
- Shared Selection and Genetic Architecture Drive Strikingly Repeatable Evolution in Long-Term Experimental Hybrid Populations.Molecular biology and evolution · 2025Article
- Article
- The genetic architecture and evolution of the human skeletal form.Science (New York, N.Y.) · 2023Article
- The genetic architecture of the human skeletal form.bioRxiv : the preprint server for biology · 2023Article
- Trade-offs in muscle physiology in selectively bred high runner mice.The Journal of experimental biology · 2022Article
- Effects of selective breeding for voluntary exercise, chronic exercise, and their interaction on muscle attachment site morphology in house mice.Journal of anatomy · 2022Article
- Haplotype tagging reveals parallel formation of hybrid races in two butterfly species.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Rapid and longer-term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice.Journal of anatomy · 2021Article
- A NaFrontiers in cell and developmental biology · 2021Article
- Estimating the genome-wide contribution of selection to temporal allele frequency change.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Can behaviour impede evolution? Persistence of singing effort after morphological song loss in crickets.Biology letters · 2020Article
- Developmental and Evolutionary Allometry of the Mammalian Limb Skeleton.Integrative and comparative biology · 2019Review
- An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice.eLife · 2019Article
- The genetic architecture of teosinte catalyzed and constrained maize domestication.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Education, Smoking, and Cohort Change: Forwarding a Multidimensional Theory of the Environmental Moderation of Genetic Effects.American sociological review · 2018Article
- Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth.Scientific reports · 2017Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMammals show a predictable scaling relationship between limb bone size and body mass. This relationship has a genetic basis which likely evolved via natural selection, but it is unclear how much the genetic correlation between these traits in turn impacts their capacity to evolve independently. We selectively bred laboratory mice for increases in tibia length independent of body mass, to test the hypothesis that a genetic correlation with body mass constrains evolutionary change in tibia length.
resultsOver 14 generations, we produced mean tibia length increases of 9-13%, while mean body mass was unchanged, in selectively bred mice and random-bred controls. Using evolutionary scenarios with different selection and quantitative genetic parameters, we also found that this genetic correlation impedes the rate of evolutionary change in both traits, slowing increases in tibia length while preventing decreases in body mass, despite the latter's negative effect on fitness.
conclusionsOverall, results from this ongoing selection experiment suggest that parallel evolution of relatively longer hind limbs among rodents, for example in the context of strong competition for resources and niche partitioning in heterogeneous environments, may have occurred very rapidly on geological timescales, in spite of a moderately strong genetic correlation between tibia length and body mass.
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