ArticleRehabilitation psychology2015
Predictors of anxiety in multiple sclerosis.
Article in Rehabilitation psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review.Nutrients · 2021Pooled it
- A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications.Journal of neurology · 2021Pooled it
- Aging and the neuropsychiatry of multiple sclerosis: a cross-sectional study.Journal of neurology · 2025Article
- Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis.JAMA network open · 2025Article
- Behavioral disorders in multiple sclerosis: a comprehensive review.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Article
- Association of Anxiety with Uncinate Fasciculus Lesion Burden in Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2024Article
- Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis.IBRO neuroscience reports · 2024Article
- Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis.Translational psychiatry · 2023Review
- Emotional Recognition and Its Relation to Cognition, Mood and Fatigue in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis.International journal of environmental research and public health · 2022Article
- Subjective cognitive impairment is related to work status in people with multiple sclerosis.IBRO neuroscience reports · 2022Article
- Anxiety Sensitivity and Its Relation to Anxiety in Multiple Sclerosis.Psychiatry and clinical psychopharmacology · 2021Article
- Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis.International journal of molecular sciences · 2021Review
- Psychiatric disorders in multiple sclerosis.Journal of neurology · 2021Review
- Psychiatric and physical comorbidities and pain in patients with multiple sclerosis.Journal of pain research · 2018Article
- Anxiety, emotional processing and depression in people with multiple sclerosis.BMC neurology · 2017Article
- Mental Health Comorbidity in MS: Depression, Anxiety, and Bipolar Disorder.Current neurology and neuroscience reports · 2016Review
- Predictors of Mood Disorders in Parents With Multiple Sclerosis: The Role of Disability Level, Coping Techniques, and Perceived Social Support.International journal of MS careArticle
- Work difficulties in people with multiple sclerosis: The role of anxiety, depression and coping.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
PURPOSE/
objectivesThe aims of this study were to (1) identify the predictors of symptoms of anxiety, and (2) evaluate the differential association of somatic and nonsomatic symptoms of depression on anxiety over time in persons with multiple sclerosis (MS). METHOD/
designParticipants were 513 persons with MS who previously enrolled in a study exploring the experience of living with MS and completed a 4-month follow-up survey. The main outcome measure used was the Hospital Anxiety and Depression Scale-Anxiety. Demographic, disease-associated variables (time since onset of MS, Expanded Disability Status Scale Mobility, pain, and fatigue), and Time 1 psychological variables were entered into a hierarchical regression model to examine predictors at baseline for anxiety symptoms at Time 2.
resultsA large portion of the sample was White (92%), female (82%), and had relapsing-remitting MS (57%). After adjusting for demographic and disease related variables, anxiety (β <.001), employment (β = .07), and nonsomatic depressive symptoms (β = .10) at baseline significantly predicted anxiety at Time 2, ps < .05. Interactions revealed significant effects for time since onset of MS and somatic symptoms as well as time since onset and nonsomatic symptoms, ps < .05. Nonsomatic symptoms were more linked to anxiety early in the disease and somatic symptoms were more prominently linked to anxiety later in the disease.
conclusionsFindings suggest that nonsomatic symptoms of depression and employment predict anxiety in MS. The relationship between different aspects of depression and anxiety may change over the course of the disease.
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Registered trials
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