ArticleEpigenetics2015
Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.
Article in Epigenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Methylation alterations of imprinted genes in different placental diseases.Clinical epigenetics · 2024Article
- Effects of DNA methylase inhibitors in a murine model of severe BPD.Respiratory physiology & neurobiology · 2023Article
- Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases.Scientific reports · 2022Article
- Epigenetics Beyond Fetal Growth Restriction: A Comprehensive Overview.Molecular diagnosis & therapy · 2022Review
- Epigenetic Mechanisms Responsible for the Transgenerational Inheritance of Intrauterine Growth Restriction Phenotypes.Frontiers in endocrinology · 2022Review
- Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.Clinical science (London, England : 1979) · 2021Article
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.Biology open · 2021Article
- STAT3-mediated effects of methyltransferase inhibitor 5-aza-2'-deoxycytidine on preeclampsia.American journal of translational research · 2021Article
- Review
- Differentially methylated region in bovine MIMT1 detected by small-scale whole-genome methylation sequencing.Journal of applied genetics · 2019Article
- Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation.Epigenetics · 2019Article
- Differential placental DNA methylation of VEGFA and LEP in small-for-gestational age fetuses with an abnormal cerebroplacental ratio.PloS one · 2019Article
- Epigenetic Signature of Chronic Maternal Stress Load During Pregnancy Might be a Potential Biomarker for Spontaneous Preterm Birth.Balkan journal of medical genetics : BJMG · 2018Article
- Genome-wide DNA methylation analysis in jejunum of Sus scrofa with intrauterine growth restriction.Molecular genetics and genomics : MGG · 2018Article
- Oxidative Stress in Preeclampsia and Placental Diseases.International journal of molecular sciences · 2018Review
- Association of Interleukin-10 Methylation Levels With Gestational Diabetes in a Taiwanese Population.Frontiers in genetics · 2018Article
- Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation.Epigenetics · 2018Article
- Placental surface area mediates the association betweenClinical epigenetics · 2018Article
- H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction.Clinical epigenetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Fetal growth is determined by the feto-placental genome interacting with the maternal in utero environment. Failure of this interplay leads to poor placental development and fetal growth restriction (FGR), which is associated with future metabolic disease. We investigated whether whole genome methylation differences existed in umbilical cord blood and placenta, between gestational-matched, FGR, and appropriately grown (AGA) neonates. Using the Infinium HumanMethylation450 BeadChip®, we found that DNA from umbilical cord blood of FGR born at term (n = 19) had 839 differentially methylated positions (DMPs) that reached genome-wide significance compared with AGA (n = 18). Using gestational age as a continuous variable, we identified 76,249 DMPs in cord blood (adj. P < 0.05) of which 121 DMPs were common to the 839 DMPs and were still evident when comparing 12 FGR with 12 AGA [39.9 ± 1.2 vs. 40.0 ± 1.0 weeks (mean ± SD), respectively]. A total of 53 DMPs had a β methylation difference >10% and 25 genes were co-methylated more than twice within 1000 base pairs. Gene Ontology (GO) analysis of DMPs supported their involvement in gene regulation and transcription pathways related to organ development and metabolic function. A similar profile of DMPs was found across different cell types in the cord blood. At term, no DMPs between FGR and AGA placentae reached genome-wide significance, validated with an external dataset. GO analysis of 284 pre-term, placental DMPs associated with autophagy, oxidative stress and hormonal responses. Growth restricted neonates have distinct DNA methylation profiles in pre-term placenta and in cord blood at birth, which may predispose to future adult disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.