Trial reportJournal of clinical hypertension (Greenwich, Conn.)2015
Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Fructose-containing food sources and blood pressure: A systematic review and meta-analysis of controlled feeding trials.PloS one · 2023Pooled it
- High versus low-added sugar consumption for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2022Pooled it
- Different Food Sources of Fructose-Containing Sugars and Fasting Blood Uric Acid Levels: A Systematic Review and Meta-Analysis of Controlled Feeding Trials.The Journal of nutrition · 2021Pooled it
- A pilot feasibility study investigating the impact of increasing sucrose intakes on body composition and blood pressure.Journal of nutritional science · 2021Trial
- Trial
- A Touch Enabled Hemodynamic and Metabolic Monitor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Observational
- Charting the Chronology of Research on Added Sugars: A Scoping Review and Evidence Map.Nutrients · 2023Article
- Tolerable upper intake level for dietary sugars.EFSA journal. European Food Safety Authority · 2022Article
- High Fructose Intake Contributes to Elevated Diastolic Blood Pressure in Adolescent Girls: Results from The HELENA Study.Nutrients · 2021Article
- Relationship of added sugars intakes with physiologic parameters in adults: an analysis of national health and nutrition examination survey 2001-2012.AIMS public health · 2020Article
- Activation of Renal (Pro)Renin Receptor Contributes to High Fructose-Induced Salt Sensitivity.Hypertension (Dallas, Tex. : 1979) · 2017Article
- What is the appropriate upper limit for added sugars consumption?Nutrition reviews · 2017Review
- Sugars, obesity, and cardiovascular disease: results from recent randomized control trials.European journal of nutrition · 2016Review
- Role of Dietary Components in Modulating Hypertension.Journal of clinical & experimental cardiology · 2016Article
- Sweeteners and health: findings from recent research and their impact on obesity and related metabolic conditions.International journal of obesity (2005) · 2016Review
- Added sugars and risk factors for obesity, diabetes and heart disease.International journal of obesity (2005) · 2016Review
- Fructose-containing sugars and cardiovascular disease.Advances in nutrition (Bethesda, Md.) · 2015Review
- Fructose-containing sugars do not raise blood pressure or uric acid at normal levels of human consumption.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle.American journal of lifestyle medicineArticle
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of fructose, commonly consumed with sugars by humans, on blood pressure and uric acid has yet to be defined. A total of 267 weight-stable participants drank sugar-sweetened milk every day for 10 weeks as part of their usual, mixed-nutrient diet. Groups 1 and 2 had 9% estimated caloric intake from fructose or glucose, respectively, added to milk. Groups 3 and 4 had 18% of estimated caloric intake from high fructose corn syrup or sucrose, respectively, added to the milk. Blood pressure and uric acid were determined prior to and after the 10-week intervention. There was no effect of sugar type on either blood pressure or uric acid (interaction P>.05), and a significant time effect for blood pressure was noted (P<.05). The authors conclude that 10 weeks of consumption of fructose at the 50th percentile level, whether consumed as pure fructose or with fructose-glucose-containing sugars, does not promote hyperuricemia or increase blood pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.