ArticleBMC psychiatry2014
Delayed circadian phase is linked to glutamatergic functions in young people with affective disorders: a proton magnetic resonance spectroscopy study.
Article in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.Early intervention in psychiatry · 2020Pooled it
- Fatigue in major depression is linked to depression severity, not sleep duration or anterior cingulate cortex neurochemistry.Journal of affective disorders · 2026Article
- Elevated oxidative stress biomarkers in adults with segmented sleep patterns.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization.Molecular psychiatry · 2024Article
- Long-term spaceflight composite stress induces depression and cognitive impairment in astronauts-insights from neuroplasticity.Translational psychiatry · 2023Review
- Are 24-hour motor activity patterns associated with continued rapid response to ketamine?Neuropsychiatric disease and treatment · 2018Article
- Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine's Rapid Antidepressant Properties.Biological psychiatry · 2017Article
- Rare deleterious mutations are associated with disease in bipolar disorder families.Molecular psychiatry · 2017Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile the association between affective disorders and sleep and circadian disturbance is well established, little is known about the neurobiology underpinning these relationships. In this study, we sought to determine the relationship between a marker of circadian rhythm and neuronal integrity (N-Acetyl Aspartate, NAA), oxidative stress (glutathione, GSH) and neuronal-glial dysfunction (Glutamate + Glutamine, Glx).
methodsFifty-three young adults (age range 15-33 years, mean = 21.8, sd = 4.3) with emerging affective disorders were recruited from a specialized tertiary referral service. Participants underwent clinical assessment and actigraphy monitoring, from which sleep midpoint was calculated as a marker of circadian rhythm. Proton magnetic resonance spectroscopy was performed in the anterior cingulate cortex (ACC). The metabolites NAA, GSH and Glx were obtained, and expressed as a ratio to Creatine.
resultsNeither NAA or GSH were associated with sleep midpoint. However, higher levels of ACC Glx were associated with later sleep midpoints (rho = 0.35, p = 0.013). This relationship appeared to be independent of age and depression severity.
conclusionsThis study is the first to demonstrate that delayed circadian phase is related to altered glutamatergic processes. It is aligned with animal research linking circadian rhythms with glutamatergic neurotransmission as well as clinical studies showing changes in glutamate with sleep interventions. Further studies may seek to examine the role of glutamate modulators for circadian misalignment.
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