ArticleNeuropsychology2015
Negative social interactions and risk of mild cognitive impairment in old age.
Article in Neuropsychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Functional social support and cognitive function in middle- and older-aged adults: a systematic review of cross-sectional and cohort studies.Systematic reviews · 2023Pooled it
- The effect of social relationships on cognitive decline in older adults: an updated systematic review and meta-analysis of longitudinal cohort studies.BMC public health · 2022Pooled it
- The impact of social activities, social networks, social support and social relationships on the cognitive functioning of healthy older adults: a systematic review.Systematic reviews · 2017Pooled it
- Social connection and cognitive health: A review of concepts, measures, and research priorities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Evaluating the association of physical frailty with cognitive impairment: a clinical perspective in older adults of Bangladesh.BMC geriatrics · 2026Article
- Cognitive function trajectories and influencing factors in Chinese older adults with self-reported hearing impairment: findings from CHARLS 2013-2020.BMC geriatrics · 2025Article
- Understanding regular exercise behavior in frail older adults: a structural equation model based on social-cognitive variables.BMC geriatrics · 2025Article
- An emotional support model in aging families: linking interaction patterns to positive mental health through social activity engagement and aging attitudes.Frontiers in public health · 2025Article
- 'With or without you': associations between noteworthy events and cognitive complaints across 100 days.Aging & mental health · 2024Article
- Psychosocial experiences are associated with human brain mitochondrial biology.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Loneliness and global cognitive functioning in racially and ethnically diverse US midlife and older adults.Frontiers in psychology · 2024Article
- Neurocognitive Features of Mild Cognitive Impairment and Distress Symptoms in Older Adults Without Major Depression.Clinical interventions in aging · 2024Article
- Social determinants of health and cognitive function: A cross-sectional study among men without dementia.Brain and behavior · 2023Article
- Age differences in functional brain networks associated with loneliness and empathy.Network neuroscience (Cambridge, Mass.) · 2023Article
- Actor and Partner Effect of Loneliness on Episodic Memory and Verbal Fluency: A Dyadic Multilevel Analysis of Romantic Couples Across 28 Countries.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Higher Dietary Intake of Advanced Glycation End Products Is Associated with Faster Cognitive Decline in Community-Dwelling Older Adults.Nutrients · 2022Article
- Personality pathology predicts increased informant-reported, but not performance-based, cognitive decline: Findings from two samples.Personality disorders · 2022Article
- Operationalizing Social Environments in Cognitive Aging and Dementia Research: A Scoping Review.International journal of environmental research and public health · 2021Article
- Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline.Journal of the American Geriatrics Society · 2021Article
- Neuroticism, negative life events, and dementia in older White and Black Brazilians.International journal of geriatric psychiatry · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that negative social interaction is associated with increased risk of mild cognitive impairment and rate of cognitive decline.
methodsParticipants were 529 older people without cognitive impairment at study onset. They completed annual evaluations that included assessment of negative social interactions (e.g., unsympathetic behavior, rejection), cognitive testing, and clinical classification of mild cognitive impairment.
resultsDuring a mean of 4.8 years of follow-up (SD = 2.5), 198 individuals (37.4%) developed mild cognitive impairment. In a proportional hazards model, higher baseline frequency of negative social interactions (M = 1.51, SD = 0.43, skewness = 1.60) was associated with higher risk of developing mild cognitive impairment (hazard ratio = 1.53, 95% confidence interval: 1.13, 2.07). Results were similar after adjustment for depressive symptoms, social network size, social activity, and loneliness. This association was mainly due to neglect and rejection. There was no change in negative social interaction rate over time (estimate = -0.003, SE = 0.004, p = .508). Higher baseline level of negative social interaction was associated with lower initial level of global cognition (estimate = -0.096, SE = 0.034, p = .005) but not with cognitive decline (estimate = -0.018, SE = 0.011, p = .098). A higher mean level of negative interactions across the study period was robustly related to faster cognitive decline (estimate = -0.036, SE = 0.012, p = .002).
conclusionFrequent negative social interactions may be a risk factor for mild cognitive impairment and cognitive decline in old age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.