Trial reportBipolar disorders2015
An Integrated Risk Reduction Intervention can reduce body mass index in individuals being treated for bipolar I disorder: results from a randomized trial.
Trial report in Bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Weight management interventions for adults living with overweight or obesity and severe mental illness: a systematic review and meta-analysis.The British journal of nutrition · 2023Pooled it
- Effectiveness of nutrition and dietary interventions for people with serious mental illness: systematic review and meta-analysis.The Medical journal of Australia · 2022Pooled it
- Interventions for the management of obesity in people with bipolar disorder.The Cochrane database of systematic reviews · 2020Pooled it
- Lifestyle interventions targeting dietary habits and exercise in bipolar disorder: A systematic review.Journal of psychiatric research · 2016Pooled it
- The effectiveness of the "SMG" model for health-promoting lifestyles among empty nesters: a community intervention trial.Health and quality of life outcomes · 2019Trial
- The role of day-to-day emotions, sleep, and social interactions in pediatric anxiety treatment.Behaviour research and therapy · 2017Trial
- Behavioral-Social Rhythms and Cardiovascular Disease Risk in Retired Night Shift Workers and Retired Day Workers.Psychosomatic medicine · 2024Article
- Lessons and Untapped Potential of Smartphone-Based Physical Activity Interventions for Mental Health: Narrative Review.JMIR mHealth and uHealth · 2024Review
- A translationally informed approach to vital signs for psychiatry: a preliminary proof of concept.NPP - digital psychiatry and neuroscience · 2024Article
- Introducing Braining-physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method.BMC psychiatry · 2023Article
- Physical Activity Monitoring Preferences in Adults With Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Improving Functioning, Quality of Life, and Well-being in Patients With Bipolar Disorder.The international journal of neuropsychopharmacology · 2019Article
- Weight Gain During Treatment of Bipolar Disorder (BD)-Facts and Therapeutic Options.Frontiers in nutrition · 2019Review
- Bipolar Disorder and Obesity: Contributing Factors, Impact on Clinical Course, and the Role of Bariatric Surgery.Current obesity reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe conducted a randomized, controlled trial comparing the efficacy of an Integrated Risk Reduction Intervention (IRRI) to a control condition with the objective of improving mood stability and psychosocial functioning by reducing cardiometabolic risk factors in overweight/obese patients with bipolar I disorder.
methodsA total of 122 patients were recruited from our outpatient services and randomly allocated to IRRI (n = 61) or psychiatric care with medical monitoring (n = 61). Individuals allocated to IRRI received psychiatric treatment and assessment, medical monitoring by a nurse, and a healthy lifestyle program from a lifestyle coach. Those allocated to the control condition received psychiatric treatment and assessment and referral, if indicated, for medical problems. A mixed-effects model was used to examine the impact of the interventions on body mass index (BMI). Exploratory moderator analyses were used to characterize those individuals likely to benefit from each treatment approach.
resultsAnalyses were conducted on data for the IRRI (n = 58) and control (n = 56) participants with ≥ 1 study visit. IRRI was associated with a significantly greater rate of decrease in BMI (d = -0.51, 95% confidence interval: -0.91 to -0.14). Three variables (C-reactive protein, total cholesterol, and instability of total sleep time) contributed to a combined moderator of faster decrease in BMI with IRRI treatment.
conclusionsOverweight/obese patients with bipolar disorder can make modest improvements in BMI, even when taking medications with known potential for weight gain. Our finding that a combination of three baseline variables provides a profile of patients likely to benefit from IRRI will need to be tested further to evaluate its utility in clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.