ReviewCNS neuroscience & therapeutics2015
Mechanisms of intrinsic epileptogenesis in human gelastic seizures with hypothalamic hamartoma.
Review in CNS neuroscience & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Intraoperative diagnosis of myxoid glioneuronal tumor guiding safe limited resection: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Massive Activation of GABABiomolecules · 2025Review
- Neural network mapping of gelastic behavior in children with hypothalamus hamartoma.World journal of pediatrics : WJP · 2024Article
- Advances in epileptic network findings of hypothalamic hamartomas.Journal of central nervous system disease · 2024Review
- Glia Signaling and Brain Microenvironment in Migraine.Molecular neurobiology · 2023Review
- Inappropriate Laughter in a Patient with Hypothalamic Hamartoma.Sultan Qaboos University medical journal · 2020Article
- Distinguishing Dependent-Stage Secondary Epileptogenesis in a Complex Case of Giant Hypothalamic Hamartoma With Assistance of a Computational Method.Frontiers in neurology · 2020Article
- Hypothalamic hamartomas in adulthood: Clinical spectrum and treatment outcome-A unicenter experience.Brain and behavior · 2019Article
- Review
- Gap Junctions Contribute to Ictal/Interictal Genesis in Human Hypothalamic Hamartomas.EBioMedicine · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Human hypothalamic hamartoma (HH) is a rare developmental malformation often characterized by gelastic seizures, which are refractory to medical therapy. Ictal EEG recordings from the HH have demonstrated that the epileptic source of gelastic seizures lies within the HH lesion itself. Recent advances in surgical techniques targeting HH have led to dramatic improvements in seizure control, which further supports the hypothesis that gelastic seizures originate within the HH. However, the basic cellular and molecular mechanisms of epileptogenesis in this subcortical lesion are poorly understood. Since 2003, Barrow Neurological Institute has maintained a multidisciplinary clinical program to evaluate and treat patients with HH. This program has provided a unique opportunity to investigate the basic mechanisms of epileptogenesis using surgically resected HH tissue. The first report on the electrophysiological properties of HH neurons was published in 2005. Since then, ongoing research has provided additional insights into the mechanisms by which HH generate seizure activity. In this review, we summarize this progress and propose a cellular model that suggests that GABA-mediated excitation contributes to epileptogenesis in HH lesions.
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Registered trials
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