ReviewNucleus (Austin, Tex.)2014
Nucleolus precursor body (NPB): a distinct structure in mammalian oocytes and zygotes.
Review in Nucleus (Austin, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Culture medium modulates nucleolar architecture and disrupts ribosomal RNA levels in preimplantation mouse embryos.The Journal of reproduction and development · 2026Article
- Nucleoskeletal Proteins in Early Embryogenesis.Advances in experimental medicine and biology · 2026Review
- How Early-Life Programming During Embryogenesis Imprints Cellular Memory.International journal of molecular sciences · 2025Review
- DTPA disrupts development of preantral ovarian follicles in vitro.Reproduction & fertility · 2025Article
- Time-series clustering of the migration speed of nucleolus-precursor bodies in human zygotes and live birth following assisted reproductive technology.Journal of assisted reproduction and genetics · 2025Article
- Spermatozoa centriole quality determined by FRAC may correlate with zygote nucleoli polarization-a pilot study.Journal of assisted reproduction and genetics · 2025Article
- Essential roles of the nucleolus during early embryonic development: a regulatory hub for chromatin organization.Open biology · 2024Article
- Nuclear Distribution of the Chromatin-Remodeling Protein ATRX in Mouse Early Embryos during Normal Development and Developmental Arrest In Vitro.Life (Basel, Switzerland) · 2023Article
- Chromatin Configuration in Diplotene Mouse and Human Oocytes during the Period of Transcriptional Activity Extinction.International journal of molecular sciences · 2023Review
- Nucleolar-basedGenes & development · 2022Article
- Non invasive assessment of human oocytes and embryos in assisted reproduction: Review on present practices and future trends.Medical journal, Armed Forces India · 2022Review
- The slippery slope antedating syngamy: pronuclear activity in preparation for the first cleavage.Journal of assisted reproduction and genetics · 2021Article
- Migration speed of nucleolus precursor bodies in human male pronuclei: a novel parameter for predicting live birth.Journal of assisted reproduction and genetics · 2021Article
- 3D time-lapse microscopy paired with endpoint lineage analysis in mouse blastocysts.STAR protocols · 2021Article
- Improving the Quality of Oocytes with the Help of Nucleolotransfer Therapy.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Nucleolus and rRNA Gene Chromatin in Early Embryo Development.Trends in genetics : TIG · 2019Review
- Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.Scientific reports · 2019Article
- Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!Reproduction (Cambridge, England) · 2016Review
- Morphokinetic features in human embryos: Analysis by our original high-resolution time-lapse cinematography-Summary of the past two decades.Reproductive medicine and biologyReview
- The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization-derived human embryo ploidy status and live birth.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleoli in mammalian oocytes and zygotes, sometimes referred to as nucleolus precursor bodies (NPBs), are compact and morphologically different from nucleoli in somatic cells. We applied a unique NPB analyzing method "enucleolation" technique to zygotes to remove the NPBs. It has been reported that oocyte NPBs are essential for embryonic development; in their absence, the oocytes complete maturation and can be fertilized, but no nucleoli are formed in the zygotes and embryos, leading to developmental failure. However, we found that when NPBs were removed from zygotes, the zygotes developed successfully to live-born pups. These results indicated that oocyte NPBs are essential for embryonic development, but zygote NPBs are not. In addition, the enucleolated zygotes formed somatic-type nucleoli during early embryonic development, demonstrating that somatic-type nucleoli do not originate from zygote NPBs. We summarize our recent investigation on NPBs, and provide additional comments and findings.
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