Evidence map›Paper›PMID 25494812›Full record

SynthesisBMC women's health2014

Risk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers.

Claudia Marchetti, Francesca De Felice, Innocenza Palaia, Giorgia Perniola, Angela Musella, Daniela Musio, Ludovico Muzii, Vincenzo Tombolini, Pierluigi Benedetti Panici

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC women's health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06497270 (A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery), which is not on this map. Cited by 87 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 7 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06497270 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2024 to 2027Enrolled3ConditionsBRCA Mutation, Estrogen Deficiency, Surgical Menopause, Menopause Related ConditionsArmsTheca and Granulosa Cell Isolation
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 7 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Assessing Psychological Morbidity in Cancer-UnaffectedCurrent oncology (Toronto, Ont.) · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Endometriosis in Carriers of a Pathogenic Variant inCurrent oncology (Toronto, Ont.) · 2025
    Article
  15. Review
  16. Article
  17. Cardiovascular Consequences of Premature Menopause.Current cardiology reports · 2025
    Review
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Claudia MarchettiDepartment of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. clamarchetti@libero.it.
Francesca De FeliceDepartment of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. fradefelice@hotmail.it.
Innocenza PalaiaDepartment of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. innocenza.palaia@uniroma1.it.
Giorgia PerniolaDepartment of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. claudia.marchetti@uniroma1.it.
Angela MusellaDepartment of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. angela.musella@gmail.com.
Daniela MusioDepartment of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. daniela.musio@libero.it.
Ludovico MuziiDepartment of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. ludovico.muzii@uniroma1.it.
Vincenzo TomboliniDepartment of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. vincenzo.tombolini@uniroma1.it.
Pierluigi Benedetti PaniciDepartment of Gynecological and Obstetrical Sciences and Urological Sciences, University of Rome 2"Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. pierluigi.benedettipanici@uniroma1.it.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWomen with BRCA1 and BRCA2 mutation carriers are at substantially elevated risk of developing ovarian cancer. The aim of the meta-analysis is to clarify the role of risk-reducing salpingo-oophorectomy (RRSO) to reduce ovarian cancer risk and mortality in women with BRCA 1 and BRCA 2 mutation carriers.

methodsPubmed, Medline and Scopus were searched to select English-language articles. Two investigators independently extracted characteristics and results of selected studies. Articles were included only if prospective and if absolute numbers of ovarian cancer and death events were available or derivable from the test. Pooled hazard ratio (HR) with 95% confidence interval (CI) was calculated using fixed effects model.

resultsMeta-analysis of 3 prospective studies demonstrated a significant risk reduction of ovarian cancer with RRSO in BRCA 1 and BRCA 2 mutation carriers, as well as benefit in all-causes mortality incidence.

conclusionsIt may be justified to recommend RRSO to reduce ovarian cancer risk and all-causes mortality in women with a mutation in BRCA 1 and BRCA 2.

Indexed as

Genes, BRCA1Genes, BRCA2OvariectomySalpingectomyCause of DeathFemaleGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansOvarian NeoplasmsPrimary PreventionRisk FactorsRisk Reduction Behavior

Identifiers

PMID25494812
PMCPMC4271468
OpenAlexW1968585700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.