ArticleBMC genetics2014
Genetics and timing of sex determination in the East African cichlid fish Astatotilapia burtoni.
Article in BMC genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Turnover of sex chromosomes in the Lake Tanganyika cichlid tribe Tropheini (Teleostei: Cichlidae).Scientific reports · 2024Article
- Evidence for selfing in a vertebrate from whole-genome sequencing.Genome research · 2023Article
- No evidence for sex chromosomes in natural populations of the cichlid fish Astatotilapia burtoni.G3 (Bethesda, Md.) · 2023Article
- Article
- Dynamics of sex chromosome evolution in a rapid radiation of cichlid fishes.Science advances · 2021Article
- Time matters! Developmental shift in gene expression between the head and the trunk region of the cichlid fish Astatotilapia burtoni.BMC genomics · 2019Article
- A Dense Linkage Map of Lake Victoria Cichlids Improved theG3 (Bethesda, Md.) · 2018Article
- FOXL2 and DMRT1L Are Yin and Yang Genes for Determining Timing of Sex Differentiation in the Bivalve MolluskFrontiers in physiology · 2018Article
- Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?Frontiers in neuroscience · 2017Review
- Germline stem cells are critical for sexual fate decision of germ cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Variations on a theme: Genomics of sex determination in the cichlid fish Astatotilapia burtoni.BMC genomics · 2016Article
- Polygenic sex determination in the cichlid fish Astatotilapia burtoni.BMC genomics · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe factors determining sex are diverse in vertebrates and especially so in teleost fishes. Only a handful of master sex-determining genes have been identified, however great efforts have been undertaken to characterize the subsequent genetic network of sex differentiation in various organisms. East African cichlids offer an ideal model system to study the complexity of sexual development, since many different sex-determining mechanisms occur in closely related species of this fish family. Here, we investigated the sex-determining system and gene expression profiles during male development of Astatotilapia burtoni, a member of the rapidly radiating and exceptionally species-rich haplochromine lineage.
resultsCrossing experiments with hormonally sex-reversed fish provided evidence for an XX-XY sex determination system in A. burtoni. Resultant all-male broods were used to assess gene expression patterns throughout development of a set of candidate genes, previously characterized in adult cichlids only.
conclusionsWe could identify the onset of gonad sexual differentiation at 11-12 dpf. The expression profiles identified wnt4B and wt1A as the earliest gonad markers in A. burtoni. Furthermore we identified late testis genes (cyp19a1A, gsdf, dmrt1 and gata4), and brain markers (ctnnb1A, ctnnb1B, dax1A, foxl2, foxl3, nanos1A, nanos1B, rspo1, sf-1, sox9A and sox9B).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.