ArticleMicrobial cell factories2014
Development of bio-based fine chemical production through synthetic bioengineering.
Article in Microbial cell factories, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 52 citations in OpenAlex.
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- Isolation of a novelFrontiers in microbiology · 2024Article
- Classification and Multifaceted Potential of Secondary Metabolites Produced byMolecules (Basel, Switzerland) · 2023Review
- Increasing Solvent Tolerance to Improve Microbial Production of Alcohols, Terpenoids and Aromatics.Microorganisms · 2021Review
- Article
- Purification and immobilization of engineered glucose dehydrogenase: a new approach to producing gluconic acid from breadwaste.Biotechnology for biofuels · 2020Article
- 5-Aminolevulinic acid fermentation using engineered Saccharomyces cerevisiae.Microbial cell factories · 2019Article
- Preferential crystallization for the purification of similar hydrophobic polyphenols.Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) · 2018Article
- Reversible bacterial immobilization based on the salt-dependent adhesion of the bacterionanofiber protein AtaA.Microbial cell factories · 2017Article
- CRISPR interference as a titratable, trans-acting regulatory tool for metabolic engineering in the cyanobacterium Synechococcus sp. strain PCC 7002.Metabolic engineering · 2016Article
- Mapping the patent landscape of synthetic biology for fine chemical production pathways.Microbial biotechnology · 2016Review
- ATP regulation in bioproduction.Microbial cell factories · 2015Review
- Synthetic biology for pharmaceutical drug discovery.Drug design, development and therapy · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fine chemicals that are physiologically active, such as pharmaceuticals, cosmetics, nutritional supplements, flavoring agents as well as additives for foods, feed, and fertilizer are produced by enzymatically or through microbial fermentation. The identification of enzymes that catalyze the target reaction makes possible the enzymatic synthesis of the desired fine chemical. The genes encoding these enzymes are then introduced into suitable microbial hosts that are cultured with inexpensive, naturally abundant carbon sources, and other nutrients. Metabolic engineering create efficient microbial cell factories for producing chemicals at higher yields. Molecular genetic techniques are then used to optimize metabolic pathways of genetically and metabolically well-characterized hosts. Synthetic bioengineering represents a novel approach to employ a combination of computer simulation and metabolic analysis to design artificial metabolic pathways suitable for mass production of target chemicals in host strains. In the present review, we summarize recent studies on bio-based fine chemical production and assess the potential of synthetic bioengineering for further improving their productivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.