ArticleThe journal of trauma and acute care surgery2014
Transfusion of stored red blood cells in trauma patients is not associated with increased procoagulant microparticles.
Article in The journal of trauma and acute care surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Exploring the utility of a novel point-of-care whole blood thrombin generation assay following trauma: A pilot study.Research and practice in thrombosis and haemostasis · 2021Article
- Thrombin generation and procoagulant microparticle profiles after acute trauma: A prospective cohort study.The journal of trauma and acute care surgery · 2015Article
- Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries.Journal of extracellular vesicles · 2015Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundWe set out to determine the effects of transfusing stored red blood cells (RBCs) on the levels of procoagulant microparticles (MPs) in the blood of trauma patients.
methodsBlood was drawn and processed to platelet poor plasma for MP analysis for 409 injured patients seen in the trauma bay from February 2011 to January 2013. Blood from 27 noninjured volunteers was also analyzed. Quantification of total procoagulant MP (per microliter plasma) using a direct plasma analysis via flow cytometry was performed. Demographic data, Injury Severity Score (ISS), overall mortality, and units of transfused packed RBCs were collected. Data are presented as median (interquartile range [IQR]). Transfusion groups were assessed using t test or Wilcoxon rank-sum test as appropriate. The α level was set as 0.05 for statistical significance.
resultsMedian ISS was 12 (IQR, 5-19), 12% were transfused, median age was 48 years (IQR, 29-62 years), 68% were male, and overall mortality was 3%. Median units transfused were 3 (IQR, 2-5). The median number of all procoagulant MP was greater in trauma patients (median 758; IQR, 405-1,627) when compared with our control subjects (median, 232; IQR, 125-372; p < 0.0001). This difference remained significant after adjusting for age and sex (p < 0.0001). In 39 patients who had MP levels measured before transfusion with RBC, the procoagulant MP levels did not change after transfusion (p = 0.07). Patients transfused with RBCs that were 14 days or older did not have increased procoagulant MP levels when compared with those that received RBCs that were younger than 14 days (p = 0.5).This was also true for those who received RBCs that were 28 days or older when compared with those that received RBCs that were younger than 28 days (p = 0.84).
conclusionProcoagulant MP is significantly greater in trauma patients as compared with volunteers, even after adjusting for age and sex. We did not observe any change in the levels of procoagulant MPs after transfusion of stored RBCs. LEVEL OF EVIDENCE: Epidemiologic/prognostic study, level III.
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