Evidence map›Paper›PMID 25494333›Full record

Trial reportPloS one2014

Complexity-Based Measures Inform Effects of Tai Chi Training on Standing Postural Control: Cross-Sectional and Randomized Trial Studies.

Peter M Wayne, Brian J Gow, Madalena D Costa, C-K Peng, Lewis A Lipsitz, Jeffrey M Hausdorff, Roger B Davis, Jacquelyn N Walsh, Matthew Lough, Vera Novak and 4 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01340365 phase2completednot on this map

Tai Chi, Physiologic Complexity, and Healthy Aging

TypeinterventionalSponsorHarvard University Faculty of MedicineRan2011 to 2013Enrolled60ConditionsHealthy AgingArmsTai Chi Exercise, Tai Chi
NCT04019301 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Caring for Caregivers With Mind-body Exercise

TypeinterventionalSponsorUniversity of HoustonRan2019 to 2022Enrolled47ConditionsCaregiver Distress, Physical Function, Quality of LifeArmsBaduanjin Qigong, Community-based, Baduanjin Qigong, Internet-based
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Peter M WayneOsher Center for Integrative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Brian J GowOsher Center for Integrative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Madalena D CostaDivision of Interdisciplinary Medicine and Biotechnology and Margret and H.A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
C-K PengDivision of Interdisciplinary Medicine and Biotechnology and Margret and H.A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America; Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan.
Lewis A LipsitzDivision of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America; Institute for Aging Research, Hebrew SeniorLife, Roslindale, Massachusetts, United States of America.
Jeffrey M HausdorffMovement Disorders Unit, Department of Neurology, Tel Aviv Medical Center, Tel Aviv, Israel; Department of Physical Therapy and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Roger B DavisDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Jacquelyn N WalshOsher Center for Integrative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Matthew LoughInstitute for Aging Research, Hebrew SeniorLife, Roslindale, Massachusetts, United States of America.
Vera NovakDivision of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Gloria Y YehDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Andrew C AhnDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Eric A MacklinBiostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Brad ManorDivision of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Beth Israel Deaconess Medical Center · USHarvard University · USBrigham and Women's Hospital · USHebrew SeniorLife · USAthinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · USTel Aviv University · IL

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Translational Researchin Aging Trainnig ProgramT32AG023480 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2004 to 2024
$7.6M
Health Outcomes of Tai Chi in Subsidized Senior HousingR01AG025037 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS, WAYNE, PETER MICHAEL · 2015 to 2019
$3.5M
Cerebrovascular Mechanisms of Slow Gait and FallsR01AG041785 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2013 to 2017
$2.4M
Nonlinear Dynamics of Frailty in AgingR37AG025037 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2006 to 2013
$1.6M
Complexity Loss, Aging and the Dynamics of FrailtyR00AG030677 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI COSTA, MADALENA D · 2011 to 2013
$733k
Tai chi, physiologic complexity, and healthy agingR21AT005501 · NCCIH · HARVARD MEDICAL SCHOOL · PI WAYNE, PETER MICHAEL · 2010 to 2012
$733k
Enhancing cerebral vasoreativity & cognition by intranasal insulin in T2DMR21DK084463 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NOVAK, VERA · 2010 to 2011
$466k
NCATS NIH HHS UL1 TR000170NCCIH NIH HHS R21 AT005501NCRR NIH HHS UL1 RR025758NIA NIH HHS R00 AG030677NIA NIH HHS R01 AG025037NIA NIH HHS R01 AG041785NIA NIH HHS R37 AG025037NIA NIH HHS T32 AG023480NIDDK NIH HHS R21 DK084463
6 · The paper itself

Abstract

backgroundDiminished control of standing balance, traditionally indicated by greater postural sway magnitude and speed, is associated with falls in older adults. Tai Chi (TC) is a multisystem intervention that reduces fall risk, yet its impact on sway measures vary considerably. We hypothesized that TC improves the integrated function of multiple control systems influencing balance, quantifiable by the multi-scale "complexity" of postural sway fluctuations.

objectivesTo evaluate both traditional and complexity-based measures of sway to characterize the short- and potential long-term effects of TC training on postural control and the relationships between sway measures and physical function in healthy older adults.

methodsA cross-sectional comparison of standing postural sway in healthy TC-naïve and TC-expert (24.5±12 yrs experience) adults. TC-naïve participants then completed a 6-month, two-arm, wait-list randomized clinical trial of TC training. Postural sway was assessed before and after the training during standing on a force-plate with eyes-open (EO) and eyes-closed (EC). Anterior-posterior (AP) and medio-lateral (ML) sway speed, magnitude, and complexity (quantified by multiscale entropy) were calculated. Single-legged standing time and Timed-Up-and-Go tests characterized physical function.

resultsAt baseline, compared to TC-naïve adults (n = 60, age 64.5±7.5 yrs), TC-experts (n = 27, age 62.8±7.5 yrs) exhibited greater complexity of sway in the AP EC (P = 0.023), ML EO (P<0.001), and ML EC (P<0.001) conditions. Traditional measures of sway speed and magnitude were not significantly lower among TC-experts. Intention-to-treat analyses indicated no significant effects of short-term TC training; however, increases in AP EC and ML EC complexity amongst those randomized to TC were positively correlated with practice hours (P = 0.044, P = 0.018). Long- and short-term TC training were positively associated with physical function.

conclusionMultiscale entropy offers a complementary approach to traditional COP measures for characterizing sway during quiet standing, and may be more sensitive to the effects of TC in healthy adults.

trial registrationClinicalTrials.gov NCT01340365.

Indexed as

Postural BalancePostureTai JiAgedAge FactorsCross-Sectional StudiesFemaleHumansMaleMiddle AgedPhysical Fitness

Identifiers

PMID25494333
PMCPMC4262457
OpenAlexW2012625125

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.