Progesterone for traumatic brain injury--resisting the sirens' song.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Effects of Progesterone on Preclinical Animal Models of Traumatic Brain Injury: Systematic Review and Meta-analysis.Molecular neurobiology · 2022
   Pooled it
2. Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials.PloS one · 2015
   Pooled it
3. Multimodal Magnetic Resonance Imaging with Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience and Clinical Condition.Neuroscience bulletin · 2025
   Article
4. Glibenclamide for Brain Contusions: Contextualizing a Promising Clinical Trial Design that Leverages an Imaging-Based TBI Endotype.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
   Review
5. Establishing ground truth in the traumatic brain injury literature: if replication is the answer, then what are the questions?Brain communications · 2023
   Review
6. How failure to falsify in high-volume science contributes to the replication crisis.eLife · 2022
   Article
7. Sex-stratified RNA-seq analysis reveals traumatic brain injury-induced transcriptional changes in the female hippocampus conducive to dementia.Frontiers in neurology · 2022
   Article
8. Genetic Variants Associated With Intraparenchymal Hemorrhage Progression After Traumatic Brain Injury.JAMA network open · 2021
   Article
9. A Population-Based Study of Pre-Existing Health Conditions in Traumatic Brain Injury.Neurotrauma reports · 2021
   Article
10. Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant.International journal of molecular sciences · 2020
    Review
11. DownstreamJournal of neurotrauma · 2019
    Article
12. Regionally clusteredJournal of neurology, neurosurgery, and psychiatry · 2018
    Article
13. Brain Monitoring Devices in Neuroscience Clinical Research: The Potential of Remote Monitoring Using Sensors, Wearables, and Mobile Devices.Clinical pharmacology and therapeutics · 2018
    Review
14. Suboptimal Dosing Parameters as Possible Factors in the Negative Phase III Clinical Trials of Progesterone for Traumatic Brain Injury.Journal of neurotrauma · 2017
    Review
15. Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury.Critical care medicine · 2017
    Article
16. A State-of-the-Science Overview of Randomized Controlled Trials Evaluating Acute Management of Moderate-to-Severe Traumatic Brain Injury.Journal of neurotrauma · 2016
    Review
17. Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice.Neurobiology of aging · 2016
    Article
18. Progesterone improves long-term functional and histological outcomes after permanent stroke in older rats.Behavioural brain research · 2016
    Article
19. Neuroprotective Role of Steroidal Sex Hormones: An Overview.CNS neuroscience & therapeutics · 2016
    Review
20. Will eye tracking change the way we diagnose and classify concussion and structural brain injury?Concussion (London, England) · 2016
    Article

Corrections and comments

• Comment on
  Very early administration of progesterone for acute traumatic brain injury.2014
• Comment on
  A clinical trial of progesterone for severe traumatic brain injury.2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as