Evidence map›Paper›PMID 25493955›Full record

SynthesisKidney international2015

Genome-wide association study of kidney function decline in individuals of European descent.

Mathias Gorski, Adrienne Tin, Maija Garnaas, Gearoid M McMahon, Audrey Y Chu, Bamidele O Tayo, Cristian Pattaro, Alexander Teumer, Daniel I Chasman, John Chalmers and 94 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 8 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 8 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

104 authors at 20 institutions in 12 countries.

Mathias Gorski1] Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany [2] Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Adrienne TinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Maija GarnaasDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gearoid M McMahon1] Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA [2] NHLBI's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Bamidele O TayoDepartment of Public Health Services, Loyola Medical Center, Loyola University Chicago, Maywood, Illinois, USA.
Cristian PattaroCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.
Alexander TeumerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
John ChalmersGeorge Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.
Pavel HametCentre de recherche du Centre hospitalier de l'Université de Montréal, University of Montreal, Montreal, Quebec, Canada.
Johanne TremblayCHUM Research Center- Technopôle Angus, Montreal, Québec, Canada.
Marc WoodwardGeorge Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.
Thor Aspelund1] Icelandic Heart Association, Research Institute, Kopavogur, Iceland [2] University of Iceland, Reykjavik, Iceland.
Gudny EiriksdottirIcelandic Heart Association, Research Institute, Kopavogur, Iceland.
Vilmundur Gudnason1] Icelandic Heart Association, Research Institute, Kopavogur, Iceland [2] University of Iceland, Reykjavik, Iceland.
Tamara B HarrisIntramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
Lenore J LaunerIntramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
Albert V Smith1] Icelandic Heart Association, Research Institute, Kopavogur, Iceland [2] University of Iceland, Reykjavik, Iceland.
Braxton D Mitchell1] Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA [2] Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jeffrey R O'ConnellDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Alan R Shuldiner1] Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA [2] Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Josef Coresh1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA [2] Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USA.
Man LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Paul FreudenbergerInstitute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Edith HoferDepartment of Neurology, Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Graz, Austria.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Reinhold SchmidtDepartment of Neurology, Medical University Graz, Graz, Austria.
Elizabeth G HollidayCentre for Clinical Epidemiology and Biostatistics, University of Newcastle, CReDITSS, HMRI, Callaghan, New South Wales, Australia.
Paul MitchellCentre for Vision Research, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia.
Jie Jin WangCentre for Vision Research, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia.
Ian H de BoerUniversity of Washington, Seattle, Washington, USA.
Guo LiCardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
David S Siscovick1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA [2] New York Academy of Medicine, New York, New York, USA.
Zoltan Kutalik1] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland [2] Department of Medical Genetics, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Tanguy CorreDepartment of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Peter VollenweiderInternal Medicine Department, Lausanne University Hospital, Lausanne, Switzerland.
Gérard WaeberInternal Medicine Department, Lausanne University Hospital, Lausanne, Switzerland.
Jayanta GuptaPerelman School of Medicine at the University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics.
Peter A KanetskyPerelman School of Medicine at the University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics.
Shih-Jen HwangNHLBI's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
Matthias Olden1] Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany [2] NHLBI's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
Qiong Yang1] NHLBI's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Mariza de AndradeMayo Clinic, Rochester, Minnesota, USA.
Elizabeth J AtkinsonMayo Clinic, Rochester, Minnesota, USA.
Sharon L R KardiaUniversity of Michigan, Ann Arbor, Michigan, USA.
Stephen T TurnerMayo Clinic, Rochester, Minnesota, USA.
Jeanette M StaffordDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jingzhong DingDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Cristina BarlassinaDepartment of Health Science, University of Milano, Milano, Italy.
Daniele Cusi1] Department of Health Science, University of Milano, Milano, Italy [2] Division of Nephrology, San Paolo Hospital, Milano, Italy.
Erika SalviDepartment of Health Science, University of Milano, Milano, Italy.
Jan A Staessen1] Department of Epidemiology, Maastricht University, Maastricht, The Netherlands [2] Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Harald Grallert1] Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany [2] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany [3] German Center for Diabetes Research, Neuherberg, Germany.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Martina Müller-Nurasyid1] DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany [3] Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany [4] Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.
Bernhard K KrämerUniversity Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Mannheim, Germany.
Holly KramerDepartment of Public Health Services, Loyola Medical Center, Loyola University Chicago, Maywood, Illinois, USA.
Sylvia E RosasJoslin Diabetes Center and Beth Israel Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Ilja M Nolte1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, Groningen, The Netherlands.
Brenda W Penninx1] Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, The Netherlands [2] EMGO Institute Vumc, NESDA, Amsterdam, The Netherlands.
Harold Snieder1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands [2] Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, Groningen, The Netherlands.
M Fabiola Del GrecoCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel, Germany.
Ute Nöthlings1] Popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany [2] Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology and Biobank popgen, Christian-Albrechts University, Kiel, Germany.
Stephan J L BakkerUniversity Medical Center Groningen, Department of Nephrology, University of Groningen, Groningen, The Netherlands.
Ron T GansevoortUniversity Medical Center Groningen, Department of Nephrology, University of Groningen, Groningen, The Netherlands.
Pim van der HarstUniversity Medical Center Groningen, Department of Cardiology, University of Groningen, Groningen, The Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Sanaz SedaghatDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Stefan CoassinDivision of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria.
Margot HaunDivision of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria.
Barbara KolleritsDivision of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria.
Florian KronenbergDivision of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria.
Bernhard PaulweberFirst Department of Internal Medicine, Paracelsus Private Medical University Salzburg, Salzburg, Austria.
Nicole AumannDepartment SHIP/KEF, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Karlhans EndlichInstitute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Mike PietznerInstitute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Rainer RettigInstitute of Physiology, University of Greifswald, Greifswald-Karlsburg, Germany.
Vincent ChourakiInserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, CHR&U de Lille, Service d'épidémiologie régional, CHRU, Lille, France.
Catherine HelmerInserm, U897, Université Bordeaux 2, ISPED, ISPED, Université Bordeaux 2, Bordeaux, France.
Jean-Charles LambertInserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, Institut Pasteur, Lille, France.
Marie MetzgerInserm, U1018, University Paris-Sud, CESP Team 10, Villejuif, France.
Benedicte StengelInserm, U1018, University Paris-Sud, CESP Team 10, Villejuif, France.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Olli Raitakari1] Department of Clinical Physiology, Turku University Hospital, Turku, Finland [2] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Andrew JohnsonNHLBI Cardiovascular Epidemiology and Human Genomics Branch, Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
Afshin ParsaDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Murielle BochudInstitute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Epalinges, Switzerland.
Iris M Heid1] Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wolfram Goessling1] Divisions of Genetics and Gastroenterology, Department of Medicine, Brigham and Women's Hospital, and Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA [2] Harvard Stem Cell Institute, Harvard University and Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Anna Köttgen1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA [2] Renal Division, Freiburg University Clinic, Germany, Freiburg, Germany.
W H Linda Kao1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA [2] Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USA.
Caroline S Fox1] NHLBI's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA [2] Department of Endocrinology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Brigham and Women's Hospital · USErasmus MC · NLJohns Hopkins University · USUniversity Medical Center Groningen · NLHelmholtz Zentrum München · DEInnsbruck Medical University · ATMedical University of Graz · ATThe University of Sydney · AUUniversity of Maryland, Baltimore · USInserm · FRMayo Clinic · USNational Heart Lung and Blood Institute · USUniversität Greifswald · DEUniversitätsmedizin Greifswald · DEUniversity of Iceland · ISUniversity of Lausanne · CHUniversity of Milan · ITWake Forest University · USChristian-Albrechts-Universität zu Kiel · DEEurac Research · IT

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI REBECCA LUCY HULL-MEICHLE · 1986 to 2026
$41.4M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2002 to 2009
$20.2M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Clinical Research Career Development (RMI)K12RR023250 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2005 to 2009
$13.3M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Intramural NIH HHSNCATS NIH HHS UL1 TR000135NCRR NIH HHS K12 RR023250NCRR NIH HHS K12RR023250NCRR NIH HHS M01 RR000425NCRR NIH HHS M01RR00425NCRR NIH HHS M01 RR016500NCRR NIH HHS M01 RR 16500NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1-RR-024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-85079-01-HC-85086NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL088119NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS R01 HL-87660NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL072515-06NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL084756NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01-AG-1-2100NIA NIH HHS R01 AG018728NIA NIH HHS R01 AG032098NIA NIH HHS R01 AG18728NIDDK NIH HHS 1 R01 DK075787-01A1NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK090311NIGMS NIH HHS U01 GM074518NIGMS NIH HHS U01 GM074518-04NIH HHS R24 OD017870NIMH NIH HHS MH081802NIMH NIH HHS R01 MH059160NIMH NIH HHS R01 MH081802PHS HHS HHSN268200625226CWellcome Trust
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS meta-analysis among 63,558 participants of European descent, initially from 16 cohorts with serial kidney function measurements within the CKDGen Consortium, followed by independent replication among additional participants from 13 cohorts. In stage 1 GWAS meta-analysis, single-nucleotide polymorphisms (SNPs) at MEOX2, GALNT11, IL1RAP, NPPA, HPCAL1, and CDH23 showed the strongest associations for at least one trait, in addition to the known UMOD locus, which showed genome-wide significance with an annual change in eGFR. In stage 2 meta-analysis, the significant association at UMOD was replicated. Associations at GALNT11 with Rapid Decline (annual eGFR decline of 3 ml/min per 1.73 m(2) or more), and CDH23 with eGFR change among those with CKD showed significant suggestive evidence of replication. Combined stage 1 and 2 meta-analyses showed significance for UMOD, GALNT11, and CDH23. Morpholino knockdowns of galnt11 and cdh23 in zebrafish embryos each had signs of severe edema 72 h after gentamicin treatment compared with controls, but no gross morphological renal abnormalities before gentamicin administration. Thus, our results suggest a role in the deterioration of kidney function for the loci GALNT11 and CDH23, and show that the UMOD locus is significantly associated with kidney function decline.

Indexed as

AnimalsCadherin Related ProteinsCadherinsGenome, HumanGenome-Wide Association StudyGlomerular Filtration RateHumansN-AcetylgalactosaminyltransferasesRenal InsufficiencyUromodulinWhite PeopleCadherin Related ProteinsCadherinsCDH23 protein, humanGALNT11 protein, humanN-AcetylgalactosaminyltransferasesUMOD protein, humanUromodulin

Identifiers

PMID25493955
PMCPMC4425568
OpenAlexW2171315731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.