Evidence map›Paper›PMID 25493637›Full record

ReviewMolecules (Basel, Switzerland)2014

Role of Protease-Inhibitors in Ocular Diseases.

Nicola Pescosolido, Andrea Barbato, Antonia Pascarella, Rossella Giannotti, Martina Genzano, Marcella Nebbioso

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  12. Observational
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  17. Review
  18. The Pathogenesis of Staphylococcus aureus Eye Infections.Pathogens (Basel, Switzerland) · 2018
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicola PescosolidoDepartment of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Policlinico Umberto I, Faculty of Medicine and Odontology, Sapienza University of Rome, piazzale Aldo Moro 5, Rome 00185, Italy.
Andrea BarbatoDepartment of Sense Organs, Ocular Electrophysiology Center, Policlinico Umberto I, Faculty of Medicine and Odontology, Sapienza University of Rome, piazzale Aldo Moro 5, Rome 00185, Italy.
Antonia PascarellaDepartment of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, piazzale Aldo Moro 5, Rome 00185, Italy.
Rossella GiannottiDepartment of Sense Organs, Ocular Electrophysiology Center, Policlinico Umberto I, Faculty of Medicine and Odontology, Sapienza University of Rome, piazzale Aldo Moro 5, Rome 00185, Italy.
Martina GenzanoDepartment of Sense Organs, Ocular Electrophysiology Center, Policlinico Umberto I, Faculty of Medicine and Odontology, Sapienza University of Rome, piazzale Aldo Moro 5, Rome 00185, Italy.
Marcella NebbiosoDepartment of Sense Organs, Ocular Electrophysiology Center, Policlinico Umberto I, Faculty of Medicine and Odontology, Sapienza University of Rome, piazzale Aldo Moro 5, Rome 00185, Italy. marcella.nebbioso@uniroma1.it.
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases. In particular, research has focused on keratoconus, corneal wounds and ulcers, keratitis, endophthalmitis, age-related macular degeneration, Sorsby fundus dystrophy, loss of nerve cells and photoreceptors during optic neuritis both in vivo and in vitro models. Protease-inhibitors have been extensively studied, rather than proteases, because they may represent a therapeutic approach for some ocular diseases. The protease-inhibitors mainly involved in the onset of the above-mentioned ocular pathologies are: α2-macroglobulin, α1-proteinase inhibitor (α1-PI), metalloproteinase inhibitor (TIMP), maspin, SERPINA3K, SERPINB13, secretory leukocyte protease inhibitor (SLPI), and calpeptin. This review is focused on the several characteristics of dysregulation of this system and, particularly, on a possible role of proteases and protease-inhibitors in molecular remodeling that may lead to some ocular diseases. Recently, researchers have even hypothesized a possible therapeutic effect of the protease-inhibitors in the treatment of injured eye in animal models.

Identifiers

PMID25493637
PMCPMC6271012
OpenAlexW2054772136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.