ArticleInternational journal of molecular sciences2014
Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of MTHFR and DNMT-1 Gene Polymorphisms with Acute Coronary Syndrome in Patients Admitted to the Emergency Department.Journal of clinical medicine · 2025Article
- Gene-wide significant association analyses ofFrontiers in genetics · 2023Article
- Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.Environmental epigenetics · 2022Review
- Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study.Lipids in health and disease · 2019Article
- Apolipoprotein E polymorphisms contribute to statin response in Chinese ASCVD patients with dyslipidemia.Lipids in health and disease · 2019Article
- krCRISPR: an easy and efficient strategy for generating conditional knockout of essential genes in cells.Journal of biological engineering · 2019Article
- Associations of ChREBP and Global DNA Methylation with Genetic and Environmental Factors in Chinese Healthy Adults.PloS one · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Recently, a significant epigenetic component in the pathogenesis of Coronary Artery Disease (CAD) has been realized. Here, we evaluated the possible association of candidate Single Nucleotide Polymorphisms (SNPs) in the epigenetic-regulatory gene, DNA methyltransferase 1 (DNMT1), with CAD in Chinese Han population. Five tag SNPs (rs16999593, rs2336691, rs2228611, rs4804494, rs7253062) were analyzed by High Resolution Melt (HRM) method in 476 CAD patients and 478 controls. Overall, there were significant differences in the genotype and allele distributions of rs2228611 and rs2336691, between patients and controls. The minor A allele of rs2228611 was associated with a lower risk of CAD (p = 0.034); modest effect in the additive analysis but also marginal significance was found in the recessive model [OR
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