ArticlePloS one2014
Maternal Grand Multiparity and the Risk of Severe Mental Disorders in Adult Offspring.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- The developmental origins of suicide mortality: a systematic review of longitudinal studies.European child & adolescent psychiatry · 2024Pooled it
- Maternal Eating Disorders, Body Mass Index, and Offspring Psychiatric Diagnoses.JAMA network open · 2024Article
- Prevalence and Sociodemographic Profiles of Grand Multipara in Abu Dhabi, United Arab Emirates.Nutrients · 2022Article
- Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland.Scientific reports · 2021Article
- Hypertensive disorders of pregnancy and emotional and behavioural problems in children: a longitudinal population-based study.European child & adolescent psychiatry · 2020Article
- C9orf72 hexanucleotide repeat length in older population: normal variation and effects on cognition.Neurobiology of aging · 2019Article
- Transition to parenthood and mental health at 30 years: a prospective comparison of mothers and fathers in a large Brazilian birth cohort.Archives of women's mental health · 2019Article
- Non-Genetic Factors in Schizophrenia.Current psychiatry reports · 2019Review
- Maternal and community factors associated with unmet contraceptive need among childbearing women in Northern Nigeria.Contraception and reproductive medicine · 2019Article
- Maternal grand multiparity and intention to use modern contraceptives in Nigeria.BMC public health · 2018Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have shown that maternal grand multiparity may predict an increased risk of mental disorders in young adult offspring, but whether such effects persist throughout adulthood remains unknown. The current study examined if maternal grand multiparity predicts the risks of severe mental disorders, suicides, suicide attempts and dementias throughout adult life.
methodsOur study sample comprised 13243 Helsinki Birth Cohort Study 1934-1944 participants (6905 men and 6338 women). According to hospital birth records, 341 offspring were born to grand multiparous mothers. From Finnish national hospital discharge and causes of death registers, we identified 1682 participants diagnosed with mental disorders during 1969-2010.
resultsMaternal grand multiparity predicted significantly increased risks of mood disorders (Hazard Ratio = 1.64, p = 0.03), non-psychotic mood disorders (Hazard Ratio = 2.02, p = 0.002), and suicide attempts (Hazard Ratio = 3.94, p = 0.01) in adult offspring. Furthermore, women born to grand multiparous mothers had significantly increased risks of any severe mental disorder (Hazard Ratio = 1.79, p = 0.01), non-psychotic substance use disorders (Hazard Ratio = 2.77, p = 0.02) schizophrenia, schizotypal and delusional disorders (Hazard Ratio = 2.40, p = 0.02), mood disorders (Hazard Ratio = 2.40, p = 0.002), non-psychotic mood disorders (Hazard Ratio = 2.91, p<0.001), and suicide attempts (Hazard Ratio = 5.05, p = 0.01) in adulthood. The effects of maternal grand multiparity on offspring psychopathology risk were independent of maternal age and body mass index at childbirth, and of year of birth, sex, childhood socioeconomic position, and birth weight of the offspring. In contrast, no significant effects were found among men.
conclusionsWomen born to grand multiparous mothers are at an increased risk of severe mental disorders and suicide attempts across adulthood. Our findings may inform the development of preventive interventions for mental disorders.
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