Evidence map›Paper›PMID 25493286›Full record

ArticleAnnals of clinical and translational neurology2014

Greatest rapid eye movement sleep atonia loss in men and older age.

Stuart J McCarter, Erik K St Louis, Bradley F Boeve, David J Sandness, Michael H Silber

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stuart J McCarterMayo Center for Sleep Medicine, Mayo Clinic and Foundation Rochester, Minnesota.
Erik K St LouisMayo Center for Sleep Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic College of Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic Department of Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic Department of Neurology, Mayo Clinic and Foundation Rochester, Minnesota.
Bradley F BoeveMayo Center for Sleep Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic College of Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic Department of Neurology, Mayo Clinic and Foundation Rochester, Minnesota.
David J SandnessMayo Center for Sleep Medicine, Mayo Clinic and Foundation Rochester, Minnesota.
Michael H SilberMayo Center for Sleep Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic College of Medicine, Mayo Clinic and Foundation Rochester, Minnesota ; Mayo Clinic Department of Neurology, Mayo Clinic and Foundation Rochester, Minnesota.
Mayo Clinic · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
NCATS NIH HHS UL1 TR000135NCRR NIH HHS UL1 RR024150NIA NIH HHS P50 AG016574
6 · The paper itself

Abstract

To determine quantitative REM sleep muscle tone in men and women without REM sleep behavior disorder, we quantitatively analyzed REM sleep phasic and tonic muscle activity, phasic muscle burst duration, and automated REM atonia index in submentalis and anterior tibialis muscles in 25 men and 25 women without REM sleep behavior disorder. Men showed significantly higher anterior tibialis phasic muscle activity. Higher phasic muscle activity was independently associated with male sex and older age in multivariate analysis. Men and the elderly may be biologically predisposed to altered REM sleep muscle atonia control, and/or some may have occult neurodegenerative disease, possibly underlying the predominance of older men with REM sleep behavior disorder.

Identifiers

PMID25493286
PMCPMC4241799
OpenAlexW2029116325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.