Evidence map›Paper›PMID 25493282›Full record

ArticleAnnals of clinical and translational neurology2014

Subplate in a rat model of preterm hypoxia-ischemia.

Chika Okusa, Franziska Oeschger, Vanessa Ginet, Wei-Zhi Wang, Anna Hoerder-Suabedissen, Tomohiro Matsuyama, Anita C Truttmann, Zoltán Molnár

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Transient Hypoxemia Chronically Disrupts Maturation of Preterm Fetal Ovine Subplate Neuron Arborization and Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  10. Review
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Chika OkusaDepartment of Physiology, Anatomy and Genetics, University of Oxford Oxford, United Kingdom ; Institute for Advanced Medical Sciences, Hyogo College of Medicine Hyogo, Japan.
Franziska OeschgerDepartment of Physiology, Anatomy and Genetics, University of Oxford Oxford, United Kingdom.
Vanessa GinetDivision of Neonatology, Department of Pediatrics, University Hospital Center and University of Lausanne Lausanne, Switzerland.
Wei-Zhi WangDepartment of Physiology, Anatomy and Genetics, University of Oxford Oxford, United Kingdom.
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy and Genetics, University of Oxford Oxford, United Kingdom.
Tomohiro MatsuyamaInstitute for Advanced Medical Sciences, Hyogo College of Medicine Hyogo, Japan.
Anita C TruttmannDivision of Neonatology, Department of Pediatrics, University Hospital Center and University of Lausanne Lausanne, Switzerland.
Zoltán MolnárDepartment of Physiology, Anatomy and Genetics, University of Oxford Oxford, United Kingdom.
University of Oxford · GBHyogo Medical University · JPUniversity of Lausanne · CH

Funding

ADA3: a novel target for HPV16 E6 oncoproteinR01CA094143 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAND, VIMLA · 2002 to 2006
$1.7M
Medical Research Council G0700377Medical Research Council G0900901NCI NIH HHS R01 CA094143
6 · The paper itself

Abstract

objectiveHypoxia-ischemia (HI) in preterm infants primarily leads to injuries in the cerebral white matter. However, there is growing evidence that perinatal injury in preterms can also involve other zones including the cortical gray matter. In a neonatal rat model of HI, selective vulnerability of subplate has been suggested using BrdU birth-dating methods. In this study, we aimed to investigate the neuropathological changes of the subplate and deep layers of the cortex following cerebral HI in neonatal rats with specific cell markers.

methodsP2 rats underwent permanent occlusion of the right common carotid artery followed by a period of hypoxia. P8 rats were analyzed using immunohistochemistry; subplate and deep layers cells were quantified and compared with sham-operated case.

resultsA large variability in the extent of the cerebral injury was apparent. For the three analyzed subplate populations (Nurr1+, Cplx3+, and Ctgf+ cells), no significant cell reduction was observed in mild and moderate cases. Only in severe cases, subplate cells were strongly affected, but these injuries were always accompanied by the cell reductions in layers VI and V.

interpretationWe could therefore not confirm a specific vulnerability of subplate cells compared to other deep layers or the white matter in our model.

Identifiers

PMID25493282
PMCPMC4241795
OpenAlexW1566261331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.