ReviewWorld journal of clinical oncology2014
Radiation-induced sarcomas of the head and neck.
Review in World journal of clinical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Primary and radiation induced skull base osteosarcoma: a systematic review of clinical features and treatment outcomes.Journal of neuro-oncology · 2021Pooled it
- Treatment of Sinonasal Teratocarcinosarcoma: A Systematic Review and Survival Analysis.American journal of rhinology & allergy · 2021Pooled it
- Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review.Advances in therapy · 2021Pooled it
- Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk.Scientific reports · 2016Trial
- Secondary Giant Cardiac Lymphoma Treated by Stepwise Chemotherapy With Multimodal Imaging.JACC. Case reports · 2026Article
- Review
- Transoral Videolaryngoscopic Surgery for an Undifferentiated Pleomorphic Sarcoma of the Tongue Base: A Case Report.Reports (MDPI) · 2025Article
- A Case of Follicular Dendritic Cell Sarcoma of the Palatine Tonsil That Developed as a Radiation-Induced Sarcoma.Case reports in otolaryngology · 2025Article
- [Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution retrospective study].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Freiburg Neuropathology Case Conference : A 51-year-old Patient Presenting with Epistaxis and Occasional Headaches 16 Years after Diagnosis of a Grade 1 Chondrosarcoma of the Left Petrous Apex.Clinical neuroradiology · 2023Article
- Differential Expression of ATM, NF-KB, PINK1 and Foxo3a in Radiation-Induced Basal Cell Carcinoma.International journal of molecular sciences · 2023Article
- Manifestations of radiation toxicity in the head, neck, and spine: An image-based review.The neuroradiology journal · 2022Review
- Radiation-induced Sarcoma in the Head and Neck: Clinical, Imaging, Histopathological, and Therapeutic Characterization.Plastic and reconstructive surgery. Global open · 2022Article
- Chemical analysis of irradiated root dentin and its interaction with resin cements.Clinical oral investigations · 2022Article
- Tetraspanin CD9: A friend or foe of head and neck cancer (Review).Oncology reports · 2022Review
- When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation.Seminars in plastic surgery · 2021Review
- Imaging Features of Postradiotherapy Changes in Head and Neck Cancers.The Indian journal of radiology & imaging · 2021Article
- Undifferentiated pleomorphic sarcoma of the mandible.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020Article
- Radiation-Induced Sarcoma of the Head and Neck Following Radiotherapy for Nasopharyngeal Carcinoma: A Single Institutional Experience and Literature Review.Frontiers in oncology · 2020Article
- Predicted Secondary Malignancies following Proton versus Photon Radiation for Oropharyngeal Cancers.International journal of particle therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With improved outcomes associated with radiotherapy, radiation-induced sarcomas (RIS) are increasingly seen in long-term survivors of head and neck cancers, with an estimated risk of up to 0.3%. They exhibit no subsite predilection within the head and neck and can arise in any irradiated tissue of mesenchymal origin. Common histologic subtypes of RIS parallel their de novo counterparts and include osteosarcoma, chondrosarcoma, malignant fibrous histiocytoma/sarcoma nitricoxide synthase, and fibrosarcoma. While imaging features of RIS are not pathognomonic, large size, extensive local invasion with bony destruction, marked enhancement within a prior radiotherapy field, and an appropriate latency period are suggestive of a diagnosis of RIS. RIS development may be influenced by factors such as radiation dose, age at initial exposure, exposure to chemotherapeutic agents and genetic tendency. Precise pathogenetic mechanisms of RIS are poorly understood and both directly mutagenizing effects of radiotherapy as well as changes in microenvironments are thought to play a role. Management of RIS is challenging, entailing surgery in irradiated tissue and a limited scope for further radiotherapy and chemotherapy. RIS is associated with significantly poorer outcomes than stage-matched sarcomas that arise independent of irradiation and surgical resection with clear margins seems to offer the best chance for cure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.