Evidence map›Paper›PMID 25493019›Full record

ArticleWorld journal of gastroenterology2014

Applicability and efficacy of a model for prevention of perinatal transmission of hepatitis B virus infection: single center study in Egypt.

Hanaa M El-Karaksy, Lamiaa M Mohsen, Doa'a A Saleh, Mona S Hamdy, Noha A Yassin, Mohamed Farouk, Mohamed E Salit, Mortada H El-Shabrawi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pattern and interpretation of hepatitis B virus markers among pregnant women in North East Egypt.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hanaa M El-KaraksyHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Lamiaa M MohsenHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Doa'a A SalehHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Mona S HamdyHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Noha A YassinHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Mohamed FaroukHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Mohamed E SalitHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Mortada H El-ShabrawiHanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt.
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify possible maternal risk factors for hepatitis B virus (HBV) acquisition and assess the efficacy of immunoprophylaxis given to infants born to hepatitis B virus surface antigen (HBsAg) positive mothers.

methodsScreening of 2000 pregnant females was carried out using rapid test and confirmed by enzyme immunoassay. A questionnaire consisting of 20 questions about the possible risk factors for acquisition of HBV infection was filled for every pregnant HBsAg positive female in addition to at least 2 pregnant HBsAg negative females for each positive case. Infants of HBsAg positive women were offered passive and active immunoprophylaxis within the 1st 48 h after birth, in addition to 2nd and 3rd doses of HBV vaccine after 1 and 6 mo respectively. Infants were tested for HBsAg and hepatitis B surface antibodies (HBsAb) at six months of age.

resultsHBsAg was confirmed positive in 1.2% of tested pregnant women. Risk factors significantly associated with HBV positivity were; history of injections (OR = 5.65), history of seeking medical advice in a clinic (OR = 7.02), history of hospitalization (OR = 6.82), history of surgery (OR = 4) and family history of hepatitis (OR = 3.89) (P < 0.05). Dropout rate was 28% for HBsAg women whose rapid test was not confirmed and could not be reached to provide immunoprophylaxis for thier newborns. Immunoprophylaxis failure was detected in only one newborn (3.7%) who tested positive for HBsAg at 6 mo of age; and vaccine failure (seronegative to HBsAb after 4 doses of the vaccine) was detected in another one (3.7%). The success rate of the immunoprophylaxis regimen was 92.6%.

conclusionThis pilot study shows that a successful national program for prevention of perinatal transmission of HBV needs to be preceded by an awareness campaign to avoid a high dropout rate.

Indexed as

BiomarkersChi-Square DistributionEgyptFemaleHepatitis BHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHumansImmunization ScheduleInfectious Disease Transmission, VerticalOdds RatioPatient DropoutsPilot ProjectsPregnancyPregnancy Complications, InfectiousBiomarkersHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesEgyptHepatitis B virusHepatitis B virus surface antigen positive mothersImmunoprophylaxisPerinatal transmission

Identifiers

PMID25493019
PMCPMC4258575
OpenAlexW2003590572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.