ArticleWorld journal of gastroenterology2014
Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
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- Novel preoperative strategies to improve hepatocellular carcinoma resectability.Hepatobiliary surgery and nutrition · 2023Article
- Quantification of Portal Vein Vascularization Using an Automated Post-Processing Video Analysis Tool.Ultrasound international open · 2023Article
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- Function of gaseous hydrogen sulfide in liver fibrosis.BMB reports · 2022Review
- Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal hemodynamics and liver function.BMC gastroenterology · 2022Article
- A Clinical-Radiomic Model for Predicting Indocyanine Green Retention Rate at 15 Min in Patients With Hepatocellular Carcinoma.Frontiers in surgery · 2022Article
- Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus.Liver research (Beijing, China) · 2021Article
- Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.Frontiers in physiology · 2021Review
- Reconstruction of the middle hepatic vein using a vein graft from the resected portion of the liver.Surgical case reports · 2020Article
- Application of the optimized carbon monoxide rebreathing method for the measurement of total haemoglobin mass in chronic liver disease.Physiological reports · 2020Article
- Current Diagnosis and Classification of Hepatic Encephalopathy.Journal of clinical and experimental hepatology · 2018Review
- Changes in liver perfusion and function before and after percutaneous occlusion of spontaneous portosystemic shunt.Japanese journal of radiology · 2017Article
- Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus.International journal of molecular sciences · 2016Article
- Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods.Scientific reports · 2016Article
- Insect tea extract attenuates CClFood science and biotechnology · 2016Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo elucidate the correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis (AL-LC).
methodsThe subjects included 35 patients with AL-LC (34 men, 1 woman; mean age, 58.9 ± 10.7 years; median age, 61 years; range: 37-76 years). All patients were enrolled in this study after obtaining written informed consent. Liver function was measured with tests measuring albumin (Alb), prothrombin time (PT), brain natriuretic peptide (BNP), branched amino acid and tyrosine ratio (BTR), branched chain amino acid (BCAA), tyrosine, ammonia (NH3), cholinesterase (ChE), immunoreactive insulin (IRI), total bile acid (TBA), and the retention rate of indocyanine green 15 min after administration (ICG R15). Hepatic blood flow, hepatic arterial tissue blood flow (HATBF), portal venous tissue blood flow (PVTBF), and total hepatic tissue blood flow (THTBF) were simultaneously calculated using xenon computed tomography.
resultsPVTBF, HATBF and THTBF were 30.2 ± 10.4, 20.0 ± 10.7, and 50.3 ± 14.9 mL/100 mL/min, respectively. Alb, PT, BNP, BTR, BCAA, tyrosine, NH3, ChE, IRI, TBA, and ICG R15 were 3.50 ± 0.50 g/dL, 72.0% ± 11.5%, 63.2 ± 56.7 pg/mL, 4.06 ± 1.24, 437.5 ± 89.4 μmol/L, 117.7 ± 32.8 μmol/L, 59.4 ± 22.7 μg/dL, 161.0 ± 70.8 IU/L, 12.8 ± 5.0 μg/dL, 68.0 ± 51.8 μmol/L, and 28.6% ± 13.5%, respectively. PVTBF showed a significant negative correlation with ICG R15 (r = -0.468, P <0.01). No significant correlation was seen between ICG 15R, HATBF and THTBF. There was a significant correlation between PVTBF and Alb (r = 0.2499, P < 0.05), and NH₃ tended to have an inverse correlation with PVTBF (r = -0.2428, P = 0.0894). There were also many significant correlations between ICG R15 and liver function parameters, including Alb, NH3, PT, BNP, TBA, BCAA, and tyrosine (r = -0.2156, P < 0.05; r = 0.4318, P < 0.01; r = 0.4140, P < 0.01; r = 0.3610, P < 0.05; r = 0.5085, P < 0.001; r = 0.4496, P < 0.01; and r = 0.4740, P < 0.05, respectively).
conclusionOur investigation showed that there is a close correlation between liver function and hepatic blood flow.
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