Evidence map›Paper›PMID 25492945›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2016

Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.

Juan L Pablo, Geoffrey S Pitt

Abstract readReview
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. In Vivo Expression of an SCA27A-LinkedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Biallelic structural variations withinLife science alliance · 2023
    Article
  7. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Effects of FGF14 and NaThe Journal of general physiology · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Juan L PabloIon Channel Research Unit, Duke University Medical Center, Durham, NC, USA Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Geoffrey S PittIon Channel Research Unit, Duke University Medical Center, Durham, NC, USA Department of Neurobiology, Duke University Medical Center, Durham, NC, USA Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA geoffrey.pitt@duke.edu.

Funding

ORGANIZATION AND FUNCTIONS OF CELLULAR STRUCTUREST32GM007184 · NIGMS · DUKE UNIVERSITY · PI JINKS-ROBERTSON, SUE · 1985 to 2019
$18.2M
Calcium regulation and dysregulation of cardiac ion channelsR01HL071165 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2002 to 2017
$5.2M
Calmodulin regulation of Na+ channels in neurons and cardiomyocytesR01HL122967 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARX, STEVEN O, PITT, GEOFFREY S · 2015 to 2018
$2.1M
CaMKII Dysregulation and Arrhythmias in Heart FailureR01HL088089 · NHLBI · DUKE UNIVERSITY · PI PITT, GEOFFREY S · 2008 to 2011
$1.6M
Structural studies of NaV1.5 and functional implications.R01HL112918 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL071165NHLBI NIH HHS R01 HL088089NHLBI NIH HHS R01 HL112918NHLBI NIH HHS R01 HL122967NHLBI NIH HHS R01HL122967NIGMS NIH HHS T32 GM007184
6 · The paper itself

Abstract

Fibroblast growth factor homologous factors (FHFs) are a noncanonical subset of intracellular fibroblast growth factors that have been implicated in a variety of neurobiological processes and in disease. They are most prominently regulators of voltage-gated Na(+) channels (NaVs). In this review, we discuss new insights into how FHFs modulate NaVs. This is followed by a summary of a growing body of evidence that FHFs operate in much broader fashion. Finally, we highlight unknown aspects of FHF function as areas of future interest.

Indexed as

AnimalsFibroblast Growth FactorsHumansNeuronsVoltage-Gated Sodium ChannelsFibroblast Growth FactorsVoltage-Gated Sodium Channelsfibroblast growth factor homologous factorsfibroblast growth factorsneuron cell biologyspinocerebellar ataxiavoltage-gated sodium channels

Identifiers

PMID25492945
PMCPMC4555190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.