Evidence map›Paper›PMID 25492872›Full record

ArticleThe Journal of biological chemistry2015

CXCR4 receptor overexpression in mesenchymal stem cells facilitates treatment of acute lung injury in rats.

Jing-Xian Yang, Nan Zhang, Han-Wei Wang, Peng Gao, Qing-Ping Yang, Qing-Ping Wen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jing-Xian YangFrom the School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
Nan ZhangFrom the School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China, School of Pharmacy, China Medical University, Shenyang 110013, China.
Han-Wei WangFirst Affiliated Hospital, Dalian Medical University, Dalian 116011, China, and.
Peng GaoDepartment of Anesthesiology, Dalian Medical University, Dalian 116044, China.
Qing-Ping YangFrom the School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
Qing-Ping WenFirst Affiliated Hospital, Dalian Medical University, Dalian 116011, China, and wenqp050607@gmail.com.
Dalian Medical University · CNLiaoning University of Traditional Chinese Medicine · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel therapeutic regimens for tissue renewal incorporate mesenchymal stem cells (MSCs) as they differentiate into a variety of cell types and are a stem cell type that is easy to harvest and to expand in vitro. However, surface chemokine receptors, such as CXCR4, which are involved in the mobilization of MSCs, are expressed only on the surface of a small proportion of MSCs, and the lack of CXCR4 expression may underlie the low efficiency of homing of MSCs toward tissue damage, which results in a poor curative effect. Here, a rat CXCR4 expressing lentiviral vector was constructed and introduced into MSCs freshly prepared from rat bone marrow. The influence of CXCR4 expression on migration, proliferation, differentiation, and paracrine effects of MSCs was examined in vitro. The in vivo properties of CXCR4-MSCs were also investigated in a model of acute lung injury in rats induced by lipopolysaccharide. Expression of CXCR4 in MSCs significantly enhanced the chemotactic and paracrine characteristics of the cells in vitro but did not affect self-renewal or differentiation into alveolar and vascular endothelial cells. In vivo, CXCR4 improved MSC homing and colonization of damaged lung tissue, and furthermore, the transplanted CXCR4-MSCs suppressed the development of acute lung injury in part by modulating levels of inflammatory molecules and the neutrophil count. These results indicated that efficient mobilization of MSCs to sites of tissue injury may be due to CXCR4, and therefore, increased expression of CXCR4 may improve their therapeutic potential in the treatment of diseases where tissue damage develops.

Indexed as

Acute Lung InjuryAnimalsBone MarrowBronchoalveolar Lavage FluidCell DifferentiationCell MembraneCell MovementCell ProliferationChemotaxisGreen Fluorescent ProteinsInflammationLentivirusLipopolysaccharidesMaleMesenchymal Stem CellsRatsCxcr4 protein, ratGreen Fluorescent ProteinsLipopolysaccharidesReceptors, CXCR4Cell MigrationLung InjuryMesenchymal Stem Cells (MSCs)MigrationTransplantation

Identifiers

PMID25492872
PMCPMC4303655
OpenAlexW2001167671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.