ArticleBrain connectivity2015
Brain Graph Topology Changes Associated with Anti-Epileptic Drug Use.
Article in Brain connectivity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of resting-state and task-based fmri in juvenile myoclonic epilepsy.Brain imaging and behavior · 2022Pooled it
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Article
- Enhanced response inhibition in patients with drug-resistant juvenile myoclonic epilepsy: Event-related potentials evidence of excitatory-inhibitory imbalance.Epilepsia open · 2025Article
- Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory.Human brain mapping · 2025Article
- Multiple subcortical and subcortico-cortico dynamic network reconfigurations characterize focal-to-bilateral tonic-clonic seizures.Scientific reports · 2025Article
- Dynamic evolution of frontal-temporal network connectivity in temporal lobe epilepsy: A magnetoencephalography study.Human brain mapping · 2024Article
- Altered structural network in temporal lobe epilepsy with focal to bilateral tonic-clonic seizures.Annals of clinical and translational neurology · 2024Article
- Effect of Antiseizure Medication on the Salience Network in Patients with Epilepsy with Generalized Tonic-Clonic Seizures Alone.Biomedicines · 2024Article
- Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls.Experimental brain research · 2024Article
- aXonica: A support package for MRI based Neuroimaging.Biotechnology notes (Amsterdam, Netherlands) · 2024Article
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Functional brain connectivity in young adults with post-stroke epilepsy.Brain communications · 2023Article
- SEEG Functional Connectivity Measures to Identify Epileptogenic Zones: Stability, Medication Influence, and Recording Condition.Neurology · 2022Article
- Brain Small-Worldness Properties and Perceived Fatigue in Mild Cognitive Impairment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- A study of brain functional network and alertness changes in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.BMC neurology · 2022Article
- Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy.Human brain mapping · 2021Article
- Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia.The journal of headache and pain · 2021Article
- Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis.Brain and behavior · 2021Article
- Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neuroimaging studies of functional connectivity using graph theory have furthered our understanding of the network structure in temporal lobe epilepsy (TLE). Brain network effects of anti-epileptic drugs could influence such studies, but have not been systematically studied. Resting-state functional MRI was analyzed in 25 patients with TLE using graph theory analysis. Patients were divided into two groups based on anti-epileptic medication use: those taking carbamazepine/oxcarbazepine (CBZ/OXC) (n=9) and those not taking CBZ/OXC (n=16) as a part of their medication regimen. The following graph topology metrics were analyzed: global efficiency, betweenness centrality (BC), clustering coefficient, and small-world index. Multiple linear regression was used to examine the association of CBZ/OXC with graph topology. The two groups did not differ from each other based on epilepsy characteristics. Use of CBZ/OXC was associated with a lower BC. Longer epilepsy duration was also associated with a lower BC. These findings can inform graph theory-based studies in patients with TLE. The changes observed are discussed in relation to the anti-epileptic mechanism of action and adverse effects of CBZ/OXC.
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