ArticleBMC bioinformatics2014
Efficient prediction of human protein-protein interactions at a global scale.
Article in BMC bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sequence-Based Protein-Protein Interaction Prediction and Its Applications in Drug Discovery.Cells · 2025Review
- Investigating the Activities ofBiology · 2024Article
- Seminar: Scalable Preprocessing Tools for Exposomic Data Analysis.Environmental health perspectives · 2023Article
- Review
- Assessment of community efforts to advance network-based prediction of protein-protein interactions.Nature communications · 2023Article
- ADH-PPI: An attention-based deep hybrid model for protein-protein interaction prediction.iScience · 2022Article
- A computational approach to rapidly design peptides that detect SARS-CoV-2 surface protein S.NAR genomics and bioinformatics · 2022Article
- Molecular Subtyping and Outlier Detection in Human Disease Using the Paraclique Algorithm.Algorithms · 2021Article
- An Ensemble Classifier to Predict Protein-Protein Interactions by Combining PSSM-based Evolutionary Information with Local Binary Pattern Model.International journal of molecular sciences · 2019Article
- In Silico Engineering of Synthetic Binding Proteins from Random Amino Acid Sequences.iScience · 2019Article
- An integration of deep learning with feature embedding for protein-protein interaction prediction.PeerJ · 2019Article
- Graph Theoretical Analysis of Genome-Scale Data: Examination of Gene Activation Occurring in the Setting of Community-Acquired Pneumonia.Shock (Augusta, Ga.) · 2018Article
- Unbiased Protein Association Study on the Public Human Proteome Reveals Biological Connections between Co-Occurring Protein Pairs.Journal of proteome research · 2017Article
- Mapping and identification of a potential candidate gene for a novel maturity locus, E10, in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Evolution of protein-protein interaction networks in yeast.PloS one · 2017Article
- Review
- Progress and challenges in predicting protein interfaces.Briefings in bioinformatics · 2016Review
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundOur knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods.
resultsOn the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range of experiments.
conclusionsThe speed and accuracy associated with MP-PIPE can make this a potential tool to study individual human PPI networks (from genomic sequences alone) for personalized medicine.
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