ArticleParasites & vectors2014
Not "out of Nantucket": Babesia microti in southern New England comprises at least two major populations.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Host-pathogen associations inferred from bloodmeal analyses ofApplied and environmental microbiology · 2024Article
- Passive Surveillance of Human-BitingInternational journal of environmental research and public health · 2023Article
- The Global Emergence of Human Babesiosis.Pathogens (Basel, Switzerland) · 2021Review
- Semicentennial of Human Babesiosis, Nantucket Island.Pathogens (Basel, Switzerland) · 2021Review
- Polymicrobial Nature of Tick-Borne Diseases.mBio · 2019Article
- Development of a SNP barcode to genotype Babesia microti infections.PLoS neglected tropical diseases · 2019Article
- Zoonotic Babesia: A scoping review of the global evidence.PloS one · 2019Article
- Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus.Parasites & vectors · 2018Article
- A molecular algorithm to detect and differentiate human pathogens infecting Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae).Ticks and tick-borne diseases · 2018Article
- Zoonotic Babesia microti in the northeastern U.S.: Evidence for the expansion of a specific parasite lineage.PloS one · 2018Article
- Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States.BMC genomics · 2016Article
- Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions.Scientific reports · 2016Article
- A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse.Nature microbiology · 2016Article
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Authors and funding
2 authors.
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Abstract
backgroundDeer tick-transmitted human babesiosis due to Babesia microti appears to be expanding its distribution and prevalence in the northeastern United States. One hypothesis for this emergence is the introduction of parasites into new sites from areas of long-standing transmission, such as Nantucket Island, Massachusetts.
methodsWe developed a typing system based on variable number tandem repeat loci that distinguished individual B. microti genotypes. We thereby analyzed the population structure of parasites from 11 sites, representing long-standing and newly emerging transmission in southern New England (northeastern United States), and compared their haplotypes and allele frequencies to determine the most probable number of B. microti populations represented by our enzootic collections. We expected to find evidence for a point source introduction across southern New England, with all parasites clearly derived from Nantucket, the site with the most intense longstanding transmission.
resultsB. microti in southern New England comprises at least two major populations, arguing against a single source. The Nantucket group comprises Martha's Vineyard, Nantucket and nearby Cape Cod. The Connecticut/Rhode Island (CT/RI) group consists of all the samples from those states along with samples from emerging sites in Massachusetts.
conclusionsThe expansion of B. microti in the southern New England mainland is not due to parasites from the nearby terminal moraine islands (Nantucket group), but rather from the CT/RI group. The development of new B. microti foci is likely due to a mix of local intensification of transmission within relict foci across southern New England as well as long distance introduction events.
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