Trial reportSurgical endoscopy2015
Peroral endoscopic myotomy for advanced achalasia with sigmoid-shaped esophagus: long-term outcomes from a prospective, single-center study.
Trial report in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Standard length of peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Pooled it
- Mid-Term and Long-Term Outcomes of Peroral Endoscopic Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2023Pooled it
- Efficacy and Safety of Peroral Endoscopic Myotomy for Sigmoid-Type Achalasia: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Updated Systematic Review of Achalasia, with a Focus on POEM Therapy.Digestive diseases and sciences · 2020Pooled it
- The 2 years' long-term efficacy and safety of peroral endoscopic myotomy for the treatment of achalasia: a systematic review.Journal of cardiothoracic surgery · 2019Pooled it
- Safety and efficacy of POEM for treatment of achalasia: a systematic review of the literature.Surgical endoscopy · 2017Pooled it
- Anatomy-driven dysphagia after technically successful peroral endoscopic myotomy in sigmoid-shape achalasia: short-term palliation with temporary fully covered self-expanding metal stents.Clinical endoscopy · 2026Article
- Characteristics and predictors of technically difficult peroral endoscopic myotomy in esophageal motility disorders: a high-volume center analysis of 676 procedures.Surgical endoscopy · 2026Article
- Long-term outcome of peroral endoscopic myotomy for sigmoid-type achalasia: S1 vs S2 subtypes.Surgical endoscopy · 2026Article
- Esophageal morphology does not predict post-operative outcomes after peroral endoscopic myotomy.Surgical endoscopy · 2025Article
- Efficacy of laparoscopic cardiectomy combined with side overlap anastomosis for the treatment of terminal achalasia.Scientific reports · 2025Article
- The application of gastrointestinal endoscopy in children: a narrative review.Frontiers in pediatrics · 2025Review
- Does preoperative symptom duration affect outcomes following per oral endoscopic myotomy (POEM)?Surgical endoscopy · 2024Article
- Novel scale for evaluating the therapeutic efficacy of per-oral endoscopic myotomy in achalasia.Journal of gastroenterology · 2024Article
- Peroral endoscopic myotomy is an effective treatment for achalasia combined with hiatal hernia.Surgical endoscopy · 2024Article
- Role of Peroral Endoscopic Myotomy in Advanced Achalasia Cardia With Sigmoid and/or Megaesophagus: A Systematic Review and Metanalysis.Journal of neurogastroenterology and motility · 2022Article
- Combination of Symptom Profile, Endoscopic Findings, and Esophageal Mucosal Histopathology Helps to Differentiate Achalasia from Refractory Gastroesophageal Reflux Disease.Diagnostics (Basel, Switzerland) · 2021Article
- One year comprehensive prospective follow-up of achalasia patients after peroral endoscopic myotomy.Annals of medicine · 2021Article
- Peroral endoscopic myotomy for advanced achalasia with megaesophagus.Esophagus : official journal of the Japan Esophageal Society · 2021Observational
- Peroral endoscopic myotomy: techniques and outcomes.Shanghai chest · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sigmoid-shaped esophagus is considered to be the advanced stage of achalasia, in which the esophageal lumen is significantly dilated, swerved, and rotated. In consideration of the efficacy of peroral endoscopic myotomy (POEM) for early achalasia, it may also offer another option for the treatment of advanced achalasia with sigmoid-shaped esophagus. Our purpose was to evaluate the feasibility and long-term efficacy of POEM for patients with sigmoid-type achalasia.
methods32 consecutive patients with sigmoid-type achalasia (S1 type in 29 patients and S2 type in 3 patients) were prospectively included. Primary outcome was symptom relief during follow-up, defined as an Eckardt score ≤3. Secondary outcomes were procedure-related adverse events, the resting lower esophageal sphincter (LES) pressure, clinical reflux complications, and procedure-related parameters.
resultsAll cases received POEM successfully. The mean operation time was 63.7 min (range 22-130 min). No serious complications related to POEM were encountered. During a mean follow-up period of 30.0 months (range 24-44 months), treatment success was achieved e in 96.8% of cases (mean score pre- vs. post-treatment 7.8 vs. 1.4; P < 0.001). Mean LES pressure also decreased from a mean of 37.9 to 12.9 mmHg after POEM (P < 0.001). One patient experienced only partial symptom relief and additional balloon dilations were carried out to relief the symptoms twice. The overall clinical reflux complication rate of POEM for sigmoid-type achalasia was 25.8%.
conclusionThe 2-year outcomes of POEM for advanced achalasia with sigmoid-shaped esophagus were excellent, resulting in long-term symptom relief in over 96% cases and without serious complications. The morphological changes of esophagus may make subsequent endoscopic tunneling more challenging and time-consuming, but do not prevent successful POEM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.