SynthesisBMC pediatrics2014
The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects.
Synthesis in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02555865 (Aetiology of Children With Bronchiectasis in China--A Multicenter Retrospective Study), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aetiology of Children With Bronchiectasis in China--A Multicenter Retrospective Study
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Bronchiectasis in children: a systematic review of cytokine profile, immune cell phenotypes and microbiota in bronchoalveolar lavage fluid.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Demographic, clinical, and immunological features in combined immunodeficiency patients: a comparative analysis of those with and without pulmonary manifestations - a multicenter study from Iran.BMC pulmonary medicine · 2026Article
- Pediatric bronchiectasis-the importance of early diagnosis of children across the chronic wet cough spectrum.Journal of thoracic disease · 2025Review
- Bronchiectasis in Children: A Comparative Analysis of Cystic Fibrosis and Non-Cystic Fibrosis Etiologies Using the Bhalla ScoreBalkan medical journal · 2025Observational
- Radiological Patterns of Pediatric Non-cystic Fibrosis Bronchiectasis: A Retrospective Study From Oman.Cureus · 2025Article
- Utilization of Inhaled Antibiotics in Pediatric Non-Cystic Fibrosis Bronchiectasis: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2025Review
- Article
- Non-cystic fibrosis bronchiectasis in pediatrics: A cohort profile of patients with inborn errors of immunity at a referral center in Cali, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2024Observational
- Cough in Protracted Bacterial Bronchitis and Bronchiectasis.Journal of clinical medicine · 2024Article
- Association between arachidonate lipoxygenase 15,c.-292 C > T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype.Italian journal of pediatrics · 2024Article
- Article
- Etiology and clinical features of children with bronchiectasis in China: A 10-year multicenter retrospective study.The clinical respiratory journal · 2023Article
- Gastrointestinal factors associated with risk of bronchiectasis in children.Pediatric pulmonology · 2023Article
- Which side are they on? Diagnosing primary ciliary dyskinesias in low- or middle-income countries: A review and case series.African journal of thoracic and critical care medicine · 2023Review
- Global research status and trends of bronchiectasis in children from 2003 to 2022: A 20-year bibliometric analysis.Frontiers in pediatrics · 2023Article
- Non-Cystic Fibrosis Bronchiectasis in Pediatric Age: A Case Series in a Metropolitan Area of Northern Italy.Children (Basel, Switzerland) · 2022Article
- Isolated IgG2 deficiency is an independent risk factor for exacerbations in bronchiectasis.QJM : monthly journal of the Association of Physicians · 2022Article
- Article
- Neutrophil Elastase and Chronic Lung Disease.Biomolecules · 2021Review
- Relationships Between Bronchoscopy, Microbiology, and Radiology in Noncystic Fibrosis Bronchiectasis.Pediatric allergy, immunology, and pulmonology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile cystic fibrosis (CF) is the most common cause of bronchiectasis in childhood, non-CF bronchiectasis is associated with a wide variety of disorders. The objective of this study was to determine the relative prevalence and specific etiologies on non-CF bronchiectasis in childhood.
methodsEMBASE, Medline, OVID Cochrane Reviews, Directory of Open Access Journals, Open Science Directory, EPSCO information services, and OAlster were searched electronically and the bibliographies of selected studies were searched manually. The search was conducted independently by 2 authors. STUDY SELECTION: (1) any clinical trial, observational study or cross-sectional case series of 10 or more patients with a description of the conditions associated with bronchiectasis; (2) subjects aged 21 years or younger; (3) cystic fibrosis was excluded and; (4) the diagnosis was confirmed by computed tomography of the chest. DATA EXTRACTION: Patient number, age range, inclusion criteria, diagnostic criteria, patient source, and categorical and specific etiology.
resultsFrom 491 studies identified, 12 studies encompassing 989 children with non-CF bronchiectasis were selected. Sixty-three percent of the subjects had an underlying disorder. Infectious (17%), primary immunodeficiency (16%), aspiration (10%), ciliary dyskinesia (9%), congenital malformation (3%), and secondary immunodeficiency (3%) were the most common disease categories; 999 etiologies were identified. Severe pneumonia of bacterial or viral etiology and B cell defects were the most common disorders identified.
conclusionsThe majority of children with non-CF bronchiectasis have an underlying disorder. A focused history and laboratory investigated is recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.