ArticlePsychopharmacology2015
Cortical activity differs during nicotine deprivation versus satiation in heavy smokers.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Nicotine Reduction in Cigarettes: Literature Review and Gap Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Pooled it
- Effects of nicotine deprivation on current pain intensity among daily cigarette smokers.Experimental and clinical psychopharmacology · 2018Trial
- Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers.Journal of abnormal psychology · 2018Trial
- Dopaminergic genetic variation moderates the effect of nicotine on cigarette reward.Psychopharmacology · 2016Trial
- Sleep Slow-Wave and Spindle Alterations in Young Smokers Correlated With the Severity of Cigarette Exposure.Addiction biology · 2026Article
- Mapping the Digital Mind: A Meta-Analysis of EEG Biomarkers in Cognition, Emotion, and Mental Health.Brain sciences · 2026Review
- Tobacco deprivation impairs metacognitive accuracy and cognitive flexibility.Psychopharmacology · 2025Article
- Persistent impacts of smoking on resting-state EEG in male chronic smokers and past-smokers with 20 years of abstinence.Scientific reports · 2023Article
- Co-occurring tobacco and cannabis use in adolescents: Dissociable relationships with mediofrontal electrocortical activity during reward feedback processing.NeuroImage. Clinical · 2021Article
- Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal.Genes, brain, and behavior · 2016Article
- Using Electrophysiological Measures to Assess the Consumer Acceptability of Smokeless Tobacco Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Nicotine-induced cortical activation among nonsmokers with moderation by trait cognitive control.Psychopharmacology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleResearch suggests that nicotine deprivation among smokers is associated with lesser resting cortical activity (i.e., greater power density in theta and alpha-1 EEG bands and lesser power in beta bands). These changes in cortical activity may be indicative of withdrawal-related cognitive deficits, yet the markers of differences in cortical activity are not well-established.
objectiveThe objective of the study was to clarify the EEG frequency bands affected by nicotine deprivation and assess prospective moderators.
methodOne hundred twenty-four heavy smokers visited the laboratory on two occasions following overnight smoking/nicotine deprivation. Prior to collecting 3 min of resting EEG data, participants smoked two very low nicotine cigarettes (<0.05 mg nicotine yield) at one session and two moderate nicotine cigarettes (0.60 mg nicotine yield) at the other.
resultsTheta and alpha-1 band (4-7 and 8-10 Hz) was greater in the very low nicotine (deprivation) relative to higher nicotine (satiation) condition. There were no condition differences in the beta-1 and beta-2 bands (14-20 and 21-30 Hz).
conclusionsGreater slow wave resting EEG may serve as a reliable marker of decreased cortical activity during smoking deprivation and, in turn, of withdrawal-related deficits in cognitive functioning. This research may inform the development of adjunct strategies for smoking cessation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.