ArticleObesity surgery2015
Chronic Electrical Stimulation at Acupoints Reduces Body Weight and Improves Blood Glucose in Obese Rats via Autonomic Pathway.
Article in Obesity surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effect of vagus nerve stimulation on metabolism: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Ameliorative and Renoprotective Effect of Electrical Stimulation on Blood Sugar, Blood Urea Nitrogen (BUN), Creatinine Levels, and the Islets of Langerhans Weight in Diabetic Mice.Veterinary medicine international · 2022Article
- Stomach region stimulated determines effects on duodenal motility in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Obesity Animal Models for Acupuncture and Related Therapy Research Studies.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Effects of electroacupuncture on stress-induced gastric dysrhythmia and mechanisms involving autonomic and central nervous systems in functional dyspepsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Effects and Mechanisms of Vagal Nerve Stimulation on Body Weight in Diet-Induced Obese Rats.Obesity surgery · 2020Article
- Sacral nerve stimulation with appropriate parameters improves constipation in rats by enhancing colon motility mediated via the autonomic-cholinergic mechanisms.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Acupuncture Regulating Gut Microbiota in Abdominal Obese Rats Induced by High-Fat Diet.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Laserpuncture Increases Serum Concentration of Insulin-Like Growth Factor-1 in Adolescent Rats.Medical acupuncture · 2018Article
- Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats.Gastroenterology research and practice · 2018Article
- Electroacupuncture inhibits weight gain in diet-induced obese rats by activating hypothalamic LKB1-AMPK signaling.BMC complementary and alternative medicine · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate effects and mechanisms of chronic electrical stimulation at acupoints (CEA) using surgically implanted electrodes on food intake, body weight, and metabolisms in diet-induced obese (DIO) rats.
methodsThirty-six DIO rats were chronically implanted with electrodes at acupoints ST-36 (Zusanli). Three sets of parameters were tested: electrical acupuncture (EA) 1 (2-s on, 3-s off, 0.5 ms, 15 Hz, 6 mA), EA2 (same as EA1 but continuous pulses), and EA3 (same as EA2 but 10 mA). A chronic study was then performed to investigate the effects of CEA on body weight and mechanisms involving gastrointestinal hormones and autonomic functions.
resultsEA2 significantly reduced food intake without uncomfortable behaviors. CEA at EA2 reduced body weight and epididymal fat pad weight (P < 0.05). CEA reduced both postprandial blood glucose and HbA1c (P < 0.05). CEA delayed gastric emptying (P < 0.03) and increased small intestinal transit (P < 0.02). CEA increased fasting plasma level of glucagon-like peptide-1 (GLP-1) and peptide YY (P < 0.05); the increase of GLP-1 was inversely correlated with postprandial blood glucose (R (2) = 0.89, P < 0.05); and the plasma ghrelin level remained unchanged. EA increased sympathetic activity (P < 0.01) and reduced vagal activity (P < 0.01).
conclusionsCEA at ST-36 reduces body weight and improves blood glucose possibly attributed to multiple mechanisms involving gastrointestinal motility and hormones via the autonomic pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.