ArticleClinical journal of gastroenterology2014
Recurrent severe acute hepatitis caused by hypereosinophilic syndrome associated with elevated serum immunoglobulin G4 levels.
Article in Clinical journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Acute Liver Failure Due to Hypereosinophilic Syndrome Accompanied by Duodenal Perforation.Internal medicine (Tokyo, Japan) · 2022Article
- Inflammatory Pseudo-tumor of the Liver Accompanied by Eosinophilia.Internal medicine (Tokyo, Japan) · 2021Article
- Concurrent eosinophilia and IgG4-related disease in a child: A case report and review of the literature.Experimental and therapeutic medicine · 2018Article
- Article
- Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia.Clinical journal of gastroenterology · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
A 46-year-old male was admitted to our hospital with severe acute hepatitis, hypereosinophilia, and serum immunoglobulin G4 (IgG4) elevation. Plasma exchange was performed, and he was treated by prednisolone; however, his hepatitis recurred twice over the following twelve months. Transjuglar liver biopsy was performed at the third onset, which demonstrated extensive hepatocyte necrosis, congestion, and severe eosinophil infiltration. We diagnosed hypereosinophilic syndrome (HES)-related hepatitis. Although no cholangitis was detected by imaging and pathological diagnosis, IgG4-positive cells were detected in the liver and bone marrow. Furthermore, the elevation of serum IgG4 levels was associated with the eosinophil count and his clinical condition. After the addition of azathioprine to his treatment regimen, no reoccurrence was observed. IgG4-positive cells may have contributed to the severity and refractoriness of this recurrent acute HES-related hepatitis.
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