Evidence map›Paper›PMID 25491498›Full record

Trial reportEuropean journal of clinical nutrition2015

Effect of diet composition on acid-base balance in adolescents, young adults and elderly at rest and during exercise.

E-M Hietavala, J R Stout, J J Hulmi, H Suominen, H Pitkänen, R Puurtinen, H Selänne, H Kainulainen, A A Mero

Open access · bronzeAbstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  18. Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

E-M HietavalaDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
J R StoutInstitute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, USA.
J J HulmiDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
H SuominenDepartment of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
H PitkänenHonka Holding, Honkajoki, Finland.
R PuurtinenDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
H SelänneLIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland.
H KainulainenDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
A A MeroDepartment of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
University of Jyväskylä · FILIKES – Foundation for Sport and Health Sciences · FIUniversity of Central Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiets rich in animal protein and cereal grains and deficient in vegetables and fruits may cause low-grade metabolic acidosis, which may impact exercise and health. We hypothesized that (1) a normal-protein diet with high amount of vegetables and fruits (HV) induces more alkaline acid-base balance compared with a high-protein diet with no vegetables and fruits (HP) and (2) diet composition has a greater impact on acid-base balance in the elderly (ELD). SUBJECTS/

methodsIn all, 12-15 (adolescents (ADO)), 25-35 (young adults (YAD)) and 60-75 (ELD)-year-old male and female subjects (n=88) followed a 7-day HV and a 7-day HP in a randomized order and at the end performed incremental cycle ergometer tests. We investigated the effect of diet composition and age on capillary (c-pH) and urine pH (u-pH), strong ion difference (SID), partial pressure of carbon dioxide (pCO2) and total concentration of weak acids (Atot). Linear regression analysis was used to examine the contribution of SID, pCO2 and Atot to c-pH.

resultsIn YAD and ELD, c-pH (P⩽0.038) and u-pH (P<0.001) were higher at rest after HV compared with HP. During cycling, c-pH was higher (P⩽0.034) after HV compared with HP at submaximal workloads in YAD and at 75% of VO2max (maximal oxygen consumption) in ELD. The contribution of SID, pCO2 and Atot to c-pH varied widely. Gender effects or changes in acid-base balance of ADO were not detected.

conclusionsA high intake of vegetables and fruits increases blood and u-pH in YAD and ELD. ELD compared with younger persons may be more sensitive for the diet-induced acid-base changes.

Indexed as

Acid-Base EquilibriumDietFeeding BehaviorAdolescentAdultAgedCarbon DioxideChildExerciseExercise TestFemaleHomeostasisHumansHydrogen-Ion ConcentrationMaleMiddle AgedCarbon Dioxide

Identifiers

PMID25491498
OpenAlexW2073522386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.