Evidence map›Paper›PMID 25491345›Full record

ReviewACS chemical neuroscience2015

Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration.

Cody A Siciliano, Erin S Calipari, Mark J Ferris, Sara R Jones

Abstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Dopamine Pharmacodynamics: New Insights.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Enhanced heroin self-administration and distinct dopamine adaptations in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  14. Article
  15. Article
  16. Bidirectional causality between addiction and cognitive deficits.International review of neurobiology · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cody A SicilianoDepartment of Physiology and Pharmacology, Wake Forest School of Medicine , Winston-Salem, North Carolina 27157, United States.
Erin S Calipari
Mark J Ferris
Sara R Jones

Funding

TROPANE EVALUATION AND GENERAL SCIENTIFIC SERVICES COREP50DA006634 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PORRINO, LINDA J. · 1991 to 2019
$30.8M
MULTI-DISCIPLINARY TRAINING IN THE BIOLOGY OF ALCOHOLISMT32AA007565 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BRIAN A MCCOOL · 1994 to 2026
$10.1M
A Novel Animal Model of Cocaine AddictionR01DA014030 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2001 to 2015
$3.2M
Dopamine Transporter Changes Following Cocaine Self-AdministrationR01DA021325 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2007 to 2011
$1.4M
Methylphenidate, Serotonin and Dopamine InteractionsR01DA030161 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2010 to 2014
$1.4M
nAChR Sensitivity and Individual Differences in Drug Abuse VulnerabilityK99DA031791 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FERRIS, MARK J · 2012 to 2013
$188k
Cocaine-Induced Dopamine Transporter Changes are Reversed by AmphetamineF31DA035558 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROSE, JAMIE HANNAH · 2013 to 2015
$112k
The effect of methylphenidate use and abuse on dopamine system kineticsF31DA031533 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CALIPARI, ERIN · 2012 to 2013
$63k
NIAAA NIH HHS T32 AA007565NIDA NIH HHS F31 DA035558NIDA NIH HHS P50 DA006634NIDA NIH HHS R01 DA014030NIDA NIH HHS R01 DA021325NIDA NIH HHS R01 DA030161
6 · The paper itself

Abstract

A great deal of research has focused on investigating neurobiological alterations induced by chronic psychostimulant use in an effort to describe, understand, and treat the pathology of psychostimulant addiction. It has been known for several decades that dopamine neurotransmission in the nucleus accumbens is integrally involved in the selection and execution of motivated and goal-directed behaviors, and that psychostimulants act on this system to exert many of their effects. As such, a large body of work has focused on defining the consequences of psychostimulant use on dopamine signaling in the striatum as it relates to addictive behaviors. Here, we review presynaptic dopamine terminal alterations observed following self-administration of cocaine and amphetamine, as well as possible mechanisms by which these alterations occur and their impact on the progression of addiction.

Indexed as

Adaptation, BiologicalAnimalsCentral Nervous System StimulantsDopamineHumansPresynaptic TerminalsSelf AdministrationCentral Nervous System StimulantsDopamineaddictionamphetaminecocainedopamineDrug abuseself-administration

Identifiers

PMID25491345
PMCPMC4304501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.