ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.
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Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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29citing papers in PubMed, 1 pooled it
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29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
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Authors and funding
13 authors at 4 institutions in 2 countries.
Timothy Etheridge*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom t.etheridge@exeter.ac.uk.
Mizanur Rahman*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Christopher J Gaffney*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Debra Shaw*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Freya Shephard*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Jignesh Magudia*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Deepak E Solomon*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Thomas Milne*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Jerzy Blawzdziewicz*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Dumitru Constantin-Teodosiu*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Paul L Greenhaff*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Siva A Vanapalli*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Nathaniel J Szewczyk*Department of Sport and Health Science, College of Life and Environmental Sciences, and College of Engineering, Mathematics and Physical Science, University of Exeter, Exeter, United Kingdom; Departments of Chemical Engineering and Mechanical Engineering, Texas Tech University, Lubbock, Texas, USA; Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, United Kingdom; and School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom.
Medical Research Council · GBTexas Tech University · USUniversity of Nottingham · GBUniversity of Exeter · GB
Funding
Gene Networks Regulating Muscle Protein DegradationR01AR054342 · NIAMS · UNIVERSITY OF NOTTINGHAM · PI SZEWCZYK, NATHANIEL J. · 2007 to 2010
$902kMedical Research Council G0801271Medical Research Council MR/K00414X/1NIAMS NIH HHS AR-054342NIAMS NIH HHS R01 AR054342
Abstract
The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell and cell-extracellular matrix interface. A small subset of the integrin-adhesome is known to maintain normal muscle morphology. However, the importance of the entire adhesome for muscle structure and function is unknown. We used RNA interference to knock down 113 putative Caenorhabditis elegans homologs constituting most of the mammalian adhesome and 48 proteins known to localize to attachment sites in C. elegans muscle. In both cases, we found >90% of components were required for normal muscle mitochondrial structure and/or proteostasis vs. empty vector controls. Approximately half of these, mainly proteins that physically interact with each other, were also required for normal sarcomere and/or adhesome structure. Next we confirmed that the dystrophy observed in adhesome mutants associates with impaired maximal mitochondrial ATP production (P < 0.01), as well as reduced probability distribution of muscle movement forces compared with wild-type animals. Our results show that the integrin-adhesome network as a whole is required for maintaining both muscle structure and function and extend the current understanding of the full complexities of the functional adhesome in vivo.
Indexed as
Adenosine TriphosphateAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Knockdown TechniquesGenes, HelminthIntegrinsMechanotransduction, CellularMitochondria, MuscleMovementMuscle ProteinsMusclesPhenotypeRNA InterferenceAdenosine TriphosphateCaenorhabditis elegans ProteinsIntegrinsMuscle Proteinscalpaindystrophyfocal adhesionmitochondria
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