ArticleInvestigative ophthalmology & visual science2014
Long-term effects of neonatal hypoxia-ischemia on structural and physiological integrity of the eye and visual pathway by multimodal MRI.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Sex-specific effects of therapeutic hypothermia on short- and long-term microglial and astrocytic reactivity after severe neonatal hypoxia-ischemia.Metabolic brain disease · 2026Article
- Longitudinal assessment of retinal and visual pathway electrophysiology and structure after high altitude exposure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Surgical techniques and outcome assessment of a novel vascularized orthotopic rodent whole eye transplantation model.PloS one · 2025Article
- Age-associated gadolinium leakage into ocular structures in patients with acute traumatic brain injury.Journal of the neurological sciences · 2024Article
- Imaging ocular water inflow in the mouse with deuterium oxide MRI.Magnetic resonance imaging · 2023Article
- In vivo MRI evaluation of anterograde manganese transport along the visual pathway following whole eye transplantation.Journal of neuroscience methods · 2022Article
- The human brain in a high altitude natural environment: A review.Frontiers in human neuroscience · 2022Review
- Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system.Neural regeneration research · 2021Review
- Cortical Visual Impairment in Childhood: 'Blindsight' and the Sprague Effect Revisited.Brain sciences · 2021Review
- In vivo MRI evaluation of early postnatal development in normal and impaired rat eyes.Scientific reports · 2021Article
- Spectral-domain OCT changes in retina and optic nerve in children with hypoxic-ischaemic encephalopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- δ-Opioid Receptor-Nrf-2-Mediated Inhibition of Inflammatory Cytokines in Neonatal Hypoxic-Ischemic Encephalopathy.Molecular neurobiology · 2019Article
- Ophthalmic outcomes following neonatal hypoxic ischaemic encephalopathy; oculomotor, biometric and refractive data in early childhood.Eye (London, England) · 2019Article
- Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience.Frontiers in neural circuits · 2019Review
- Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma.Journal of neuroinflammation · 2018Article
- Analysis of alterations in white matter integrity of adult patients with comitant exotropia.The Journal of international medical research · 2018Article
- Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma.Scientific reports · 2018Article
- Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI.Scientific reports · 2017Article
- Magnetic resonance imaging study of eye congenital birth defects in mouse model.Molecular vision · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeNeonatal hypoxia-ischemia is a major cause of brain damage in infants and may frequently present visual impairments. Although advancements in perinatal care have increased survival, the pathogenesis of hypoxic-ischemic injury and the long-term consequences to the visual system remain unclear. We hypothesized that neonatal hypoxia-ischemia can lead to chronic, MRI-detectable structural and physiological alterations in both the eye and the brain's visual pathways.
methodsEight Sprague-Dawley rats underwent ligation of the left common carotid artery followed by hypoxia for 2 hours at postnatal day 7. One year later, T2-weighted MRI, gadolinium-enhanced MRI, chromium-enhanced MRI, manganese-enhanced MRI, and diffusion tensor MRI (DTI) of the visual system were evaluated and compared between opposite hemispheres using a 7-Tesla scanner.
resultsWithin the eyeball, systemic gadolinium administration revealed aqueous-vitreous or blood-ocular barrier leakage only in the ipsilesional left eye despite comparable aqueous humor dynamics in the anterior chamber of both eyes. Binocular intravitreal chromium injection showed compromised retinal integrity in the ipsilesional eye. Despite total loss of the ipsilesional visual cortex, both retinocollicular and retinogeniculate pathways projected from the contralesional eye toward ipsilesional visual cortex possessed stronger anterograde manganese transport and less disrupted structural integrity in DTI compared with the opposite hemispheres.
conclusionsHigh-field, multimodal MRI demonstrated in vivo the long-term structural and physiological deficits in the eye and brain's visual pathways after unilateral neonatal hypoxic-ischemic injury. The remaining retinocollicular and retinogeniculate pathways appeared to be more vulnerable to anterograde degeneration from eye injury than retrograde, transsynaptic degeneration from visual cortex injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.