ArticleBMC plant biology2014
Location of chlorogenic acid biosynthesis pathway and polyphenol oxidase genes in a new interspecific anchored linkage map of eggplant.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 113 citations in OpenAlex.
- Shaping the Plant Specialized Metabolites Through Modern Breeding Technique.Molecular biotechnology · 2026Review
- Integrated metabolomic, proteomic, and transcriptomic analyses reveal the production of bioactive metabolites and antidiabetic effects in matureFrontiers in plant science · 2026Article
- Biosynthetic Mechanisms of Plant Chlorogenic Acid from a Microbiological Perspective.Microorganisms · 2025Review
- Primary Metabolite Screening Shows Significant Differences between Embryogenic and Non-Embryogenic Callus of Tamarillo (Plants (Basel, Switzerland) · 2023Article
- A Compendium for Novel Marker-Based Breeding Strategies in Eggplant.Plants (Basel, Switzerland) · 2023Review
- Genetics and breeding of phenolic content in tomato, eggplant and pepper fruits.Frontiers in plant science · 2023Review
- Construction of a High-Density Recombination Bin-Based Genetic Map Facilitates High-Resolution Mapping of a Major QTL Underlying Anthocyanin Pigmentation in Eggplant.International journal of molecular sciences · 2022Article
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- Metabolome and Transcriptome Profiling Unveil the Mechanisms of Polyphenol Synthesis in the Developing Endopleura of Walnut (International journal of molecular sciences · 2022Article
- A revision of the "spiny solanums" of Tropical Asia (PhytoKeys · 2022Article
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- The interactive effect of aromatic amino acid composition on the accumulation of phenolic compounds and the expression of biosynthesis-related genes inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Improved genome assembly and pan-genome provide key insights into eggplant domestication and breeding.The Plant journal : for cell and molecular biology · 2021Article
- Strategies to Modulate Specialized Metabolism in Mediterranean Crops: From Molecular Aspects to Field.International journal of molecular sciences · 2021Review
- Identification of Quantitative Trait Loci Controlling the Development of Prickles in Eggplant by Genome Re-sequencing Analysis.Frontiers in plant science · 2021Article
- An Eggplant Recombinant Inbred Population Allows the Discovery of Metabolic QTLs Controlling Fruit Nutritional Quality.Frontiers in plant science · 2021Article
- Fine mapping of a major locus representing the lack of prickles in eggplant revealed the availability of a 0.5-kb insertion/deletion for marker-assisted selection.Breeding science · 2020Article
- Article
- Grown to be Blue-Antioxidant Properties and Health Effects of Colored Vegetables. Part II: Leafy, Fruit, and Other Vegetables.Antioxidants (Basel, Switzerland) · 2020Review
- Genetic Analysis for Fruit Phenolics Content, Flesh Color, and Browning Related Traits in Eggplant (International journal of molecular sciences · 2019Article
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEggplant is a powerful source of polyphenols which seems to play a key role in the prevention of several human diseases, such as cancer and diabetes. Chlorogenic acid is the polyphenol most present in eggplant, comprising between the 70% and 90% of the total polyphenol content. Introduction of the high chlorogenic acid content of wild relatives, such as S. incanum, into eggplant varieties will be of great interest. A potential side effect of the increased level polyphenols could be a decrease on apparent quality due to browning caused by the polyphenol oxidase enzymes mediated oxidation of polyphenols. We report the development of a new interspecific S. melongena × S. incanum linkage map based on a first backcross generation (BC1) towards the cultivated S. melongena as a tool for introgressing S. incanum alleles involved in the biosynthesis of chlorogenic acid in the genetic background of S. melongena.
resultsThe interspecific genetic linkage map of eggplant developed in this work anchor the most informative previously published genetic maps of eggplant using common markers. The 91 BC1 plants of the mapping population were genotyped with 42 COSII, 99 SSRs, 88 AFLPs, 9 CAPS, 4 SNPs and one morphological polymorphic markers. Segregation marker data resulted in a map encompassing 1085 cM distributed in 12 linkage groups. Based on the syntheny with tomato, the candidate genes involved in the core chlorogenic acid synthesis pathway in eggplant (PAL, C4H, 4CL, HCT, C3'H, HQT) as well as five polyphenol oxidase (PPO1, PPO2, PPO3, PPO4, PPO5) were mapped. Except for 4CL and HCT chlorogenic acid genes were not linked. On the contrary, all PPO genes clustered together. Candidate genes important in domestication such as fruit shape (OVATE, SISUN1) and prickliness were also located.
conclusionsThe achievements in location of candidate genes will allow the search of favorable alleles employing marker-assisted selection in order to develop new varieties with higher chlorogenic content alongside a lower polyphenol oxidase activity. This will result into an enhanced product showing a lower fruit flesh browning with improved human health properties.
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