ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Relationship between serum uric Acid and bone mineral density in the general population and in rats with experimental hyperuricemia.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Gout is not associated with the risk of fracture: a meta-analysis.Journal of orthopaedic surgery and research · 2019Pooled it
- The association between serum uric acid level and the risk of fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Analyses of the relationship between hyperuricemia and osteoporosis.Scientific reports · 2021Trial
- Association between the serum uric acid to HDL cholesterol ratio and forearm bone mineral density in middle-aged and older adults.Frontiers in endocrinology · 2026Article
- GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non-Obese Patients With MASLD and Hyperuricemia.The Kaohsiung journal of medical sciences · 2025Article
- Sex differences in the relationship between parathyroid hormone and uric acid in osteoporotic fracture patients: insights from a retrospective cross-sectional study.Frontiers in endocrinology · 2025Article
- The relationship between uric acid and bone mineral density in the intermediate stage of CKD 1-3.BMC nephrology · 2024Article
- A Mendelian randomization study of the association between serum uric acid and osteoporosis risk.Frontiers in endocrinology · 2024Article
- Relationship between serum uric acid levels and osteoporosis.Endocrine connections · 2023Review
- Association of serum uric acid levels with bone mineral density and the presence of osteoporosis in Chinese patients with Parkinson's disease: a cross-sectional study.Journal of bone and mineral metabolism · 2023Article
- Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2023Article
- Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population.International journal of environmental research and public health · 2023Article
- Association between serum uric acid level and bone mineral density in men more than 50 years of age.Frontiers in endocrinology · 2023Observational
- Risk factors of osteoporosis in elderly inpatients: A cross-sectional single-centre study.Frontiers in aging · 2023Article
- Relationship between bone mineral density and hyperuricemia in obesity: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Association between serum uric acid level and bone mineral density at multiple skeletal sites in middle-aged and elderly men: a cross-sectional study of a healthy population in Taiwan.Archives of osteoporosis · 2022Article
- Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study.Nutrients · 2022Article
- Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study.Healthcare (Basel, Switzerland) · 2021Article
- No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledHigher serum uric acid concentrations have been associated with higher bone mineral density (BMD) in observational studies of older men and perimenopausal or postmenopausal women, prompting speculation of a potential protective effect of uric acid on bone. Whether this relationship is present in the general population has not been examined and there is no data to support causality. We conducted a cross-sectional analysis of a probability sample of the U.S. POPULATION: Demographic data, dietary intake, lifestyle risk factors and physical activity assessment data, serum biochemistry including serum uric acid, and BMD were obtained from 6759 National Health and Nutrition Examination Survey (NHANES; 2005-2010) participants over 30 years of age. In unadjusted analyses, higher serum uric acid levels were associated with higher BMD at the femoral neck, total hip, and lumbar spine in men, premenopausal women, and postmenopausal women not treated with estrogen. However, these associations were no longer statistically significant after adjustment for potential confounders, including age, body mass index (BMI), black race, alcohol consumption, estimated glomerular filtration rate (eGFR), serum alkaline phosphatase, and C-reactive protein (CRP). This is in contradistinction to some prevailing conclusions in the literature. To further examine the causal effect of higher serum uric acid on skeletal health, including biomechanical properties that are not measurable in humans, we used an established rat model of inducible mild hyperuricemia. There were no differences in BMD, bone volume density, and bone biomechanical properties between hyperuricemic rats and normouricemic control animals. Taken together, our data do not support the hypothesis that higher serum uric acid has protective effects on bone health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.