ArticlePlant physiology2015
Pepper heat shock protein 70a interacts with the type III effector AvrBsT and triggers plant cell death and immunity.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- Molecular mechanisms and agronomic strategies for thermotolerance in chili pepper (Capsicum annuum L.).Plant cell reports · 2026Review
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- A conserved fungal effector disturbs CaNature communications · 2025Article
- A viral p3a protein targets and inhibits TaDOF transcription factors to promote the expression of susceptibility genes and facilitate viral infection.PLoS pathogens · 2024Article
- Using Transcriptomics to Determine the Mechanism for the Resistance to Fusarium Head Blight of a Wheat-International journal of molecular sciences · 2024Article
- The F-box protein OsFBX156 positively regulates rice defence against the blast fungus Magnaporthe oryzae by mediating ubiquitination-dependent degradation of OsHSP71.1.Molecular plant pathology · 2024Article
- Systematic analysis of Heat Shock Protein 70 (HSP70) gene family in radish and potential roles in stress tolerance.BMC plant biology · 2024Article
- Overexpression of the potatoFrontiers in plant science · 2024Article
- Regulation of heat shock proteins 70 and their role in plant immunity.Journal of experimental botany · 2022Review
- β-Cyclocitral, a Master Regulator of Multiple Stress-Responsive Genes inPlants (Basel, Switzerland) · 2021Article
- RNA-Seq analysis reveals potential regulators of programmed cell death and leaf remodelling in lace plant (Aponogeton madagascariensis).BMC plant biology · 2021Article
- Proteomic analysis of early-stage incompatible and compatible interactions between grapevine and P. viticola.Horticulture research · 2021Article
- iTRAQ-based quantitative proteomic analysis of heat stress-induced mechanisms in pepper seedlings.PeerJ · 2021Article
- Systemic acquired resistance specific proteome of Arabidopsis thaliana.Plant cell reports · 2020Article
- Article
- Proteomic analysis upon peach fruit infection with Monilinia fructicola and M. laxa identify responses contributing to brown rot resistance.Scientific reports · 2020Article
- iTRAQ-Based Proteomic Analysis of Watermelon Fruits in Response toInternational journal of molecular sciences · 2020Article
- Transcription FactorInternational journal of molecular sciences · 2020Article
- Heat Shock Responsive Gene Expression Modulated by mRNA Poly(A) Tail Length.Frontiers in plant science · 2020Article
- A Novel Transcription FactorInternational journal of molecular sciences · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins (HSPs) function as molecular chaperones and are essential for the maintenance and/or restoration of protein homeostasis. The genus Xanthomonas type III effector protein AvrBsT induces hypersensitive cell death in pepper (Capsicum annuum). Here, we report the identification of the pepper CaHSP70a as an AvrBsT-interacting protein. Bimolecular fluorescence complementation and coimmunoprecipitation assays confirm the specific interaction between CaHSP70a and AvrBsT in planta. The CaHSP70a peptide-binding domain is essential for its interaction with AvrBsT. Heat stress (37°C) and Xanthomonas campestris pv vesicatoria (Xcv) infection distinctly induce CaHSP70a in pepper leaves. Cytoplasmic CaHSP70a proteins significantly accumulate in pepper leaves to induce the hypersensitive cell death response by Xcv (avrBsT) infection. Transient CaHSP70a overexpression induces hypersensitive cell death under heat stress, which is accompanied by strong induction of defense- and cell death-related genes. The CaHSP70a peptide-binding domain and ATPase-binding domain are required to trigger cell death under heat stress. Transient coexpression of CaHSP70a and avrBsT leads to cytoplasmic localization of the CaHSP70a-AvrBsT complex and significantly enhances avrBsT-triggered cell death in Nicotiana benthamiana. CaHSP70a silencing in pepper enhances Xcv growth but disrupts the reactive oxygen species burst and cell death response during Xcv infection. Expression of some defense marker genes is significantly reduced in CaHSP70a-silenced leaves, with lower levels of the defense hormones salicylic acid and jasmonic acid. Together, these results suggest that CaHSP70a interacts with the type III effector AvrBsT and is required for cell death and immunity in plants.
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