ReviewACS chemical neuroscience2015
A role for phasic dopamine release within the nucleus accumbens in encoding aversion: a review of the neurochemical literature.
Review in ACS chemical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 132 citations in OpenAlex.
- Article
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- Reward processing differences in autism: current understandings and future directions.Social cognitive and affective neuroscience · 2026Review
- Subcortical neural basis of malevolent creativity.iScience · 2025Article
- Nucleus Accumbens Dopamine Levels Fluctuate Across Different States of Consciousness Under Sevoflurane Anesthesia.Brain sciences · 2025Article
- Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms.eLife · 2025Article
- A network analysis of gene co-expression in post-mortem brain tissues identifying novel genes and biological pathways underlying major depression.Frontiers in psychiatry · 2025Article
- Activation of the nucleus accumbens promotes place preference and counteracts stress-induced hyperthermia.iScience · 2024Article
- Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release.Neuron · 2024Article
- Interleukin-10 enhances activity of ventral tegmental area dopamine neurons resulting in increased dopamine release.Brain, behavior, and immunity · 2023Article
- A structural comparison of salt forms of dopamine with the structures of other phenylethylamines.Acta crystallographica. Section C, Structural chemistry · 2023Article
- Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior.Cell reports · 2023Article
- The Role of Physical Exercise in Opioid Substitution Therapy: Mechanisms of Sequential Effects.International journal of molecular sciences · 2023Review
- Neurotransmitters Regulation and Food Intake: The Role of Dietary Sources in Neurotransmission.Molecules (Basel, Switzerland) · 2022Review
- Habit Formation and the Effect of Repeated Stress Exposures on Cognitive Flexibility Learning in Horses.Animals : an open access journal from MDPI · 2022Article
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
- Article
- Threat and Bidirectional Valence Signaling in the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Characterization of cognitive function in survivors of diffuse gliomas using resting-state functional MRI (rs-fMRI).Brain imaging and behavior · 2022Article
- Neural alterations in opioid-exposed infants revealed by edge-centric brain functional networks.Brain communications · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Survival is dictated by an organism's fitness in approaching positive stimuli and avoiding harm. While a rich literature outlines a role for mesolimbic dopamine in reward and appetitive behaviors, dopamine's involvement in aversion and avoidance behaviors remains controversial. Debate surrounding dopamine's function in the processing of negative stimuli likely stems from conflicting results reported by single-unit electrophysiological studies. Indeed, a number of studies suggest that midbrain dopaminergic cells are inhibited by the presentation of negative or fearful stimuli, while others report no change, or even an increase, in their activity. These disparate results may be due to population heterogeneity. Recent evidence demonstrates that midbrain dopamine neurons are heterogeneous in their projection targets, responses to environmental stimuli, pharmacology, and influences on motivated behavior. Thus, in order to assemble an accurate account of dopamine function during aversive stimulus experience and related behavior, it is necessary to examine the functional output of dopamine neural activity at mesolimbic terminal regions. This Review presents a growing body of evidence that dopamine release in the nucleus accumbens encodes not only reward, but also aversion. For example, our laboratory recently utilized fast-scan cyclic voltammetry to show that real-time changes in accumbal dopamine release are detected when animals are presented with predictors of aversion and its avoidance. These data, along with other reports, support a considerably more nuanced view of dopamine neuron function, wherein accumbal dopamine release is differentially modulated by positive and negative affective stimuli to promote adaptive behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.