Evidence map›Paper›PMID 25491076›Full record

ReviewJournal of neurology2015

Clinical and experimental studies of potentially pathogenic brain-directed autoantibodies: current knowledge and future directions.

James Varley, Angela Vincent, Sarosh R Irani

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The clinical features, underlying immunology, and treatment of autoantibody-mediated movement disorders.Movement disorders : official journal of the Movement Disorder Society · 2018
    Review
  9. LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes.Journal of neurology, neurosurgery, and psychiatry · 2018
    Review
  10. Seronegative antibody-mediated neurology after immune checkpoint inhibitors.Annals of clinical and translational neurology · 2018
    Article
  11. Diagnosing MRI-negative autoimmune diseases.Neurology(R) neuroimmunology & neuroinflammation · 2018
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James VarleyNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, West Wing, Level 6, Oxford, OX3 9DU, UK.
Angela Vincent
Sarosh R Irani
John Radcliffe Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The field of neuronal surface-directed antibody-mediated diseases of the central nervous system has dramatically expanded in the last few years and now forms an important cluster of treatable neurological conditions. In this review, we focus on three areas. First, we review the demographics, clinical features and treatment responses of these conditions. Second, we consider their pathophysiology and compare autoantibody mechanisms and their effects to genetic or pharmacological disruptions of the target antigens. Third, we discuss areas of controversy within the field, propose possible resolutions, and explore new directions for neuronal surface antibody-mediated diseases.

Indexed as

AnimalsAutoantibodiesAutoimmune Diseases of the Nervous SystemHumansAutoantibodies

Identifiers

PMID25491076
PMCPMC4412383
OpenAlexW1982691453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.