ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
A prospective follow-up study of the relationship between C-reactive protein and human cancer risk in the Chinese Kailuan Female Cohort.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Inflammatory Biomarkers and Breast Cancer Risk: A Systematic Review of the Evidence and Future Potential for Intervention Research.International journal of environmental research and public health · 2020Pooled it
- Plasma C-reactive protein and risk of breast cancer in two prospective studies and a meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Pooled it
- C-reactive protein and risk of breast cancer: A systematic review and meta-analysis.Scientific reports · 2015Pooled it
- Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study.BMC cancer · 2022Article
- Obesity: an evolutionary context.Life metabolism · 2022Review
- C-reactive protein trajectories and the risk of all cancer types: A prospective cohort study.International journal of cancer · 2022Article
- Fasting Blood Glucose, Cholesterol, and Risk of Primary Liver Cancer: The Kailuan Study.Cancer research and treatment · 2021Article
- Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.Oncotarget · 2021Article
- Uric Acid Variability and All-Cause Mortality: A Prospective Cohort Study in Northern China.The journal of nutrition, health & aging · 2021Article
- Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China.Hepatology international · 2020Article
- The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: a cohort study.European heart journal · 2019Article
- Waist Circumference Might Be a Predictor of Primary Liver Cancer: A Population-Based Cohort Study.Frontiers in oncology · 2018Article
- The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study.British journal of cancer · 2017Article
- Biomarkers of inflammation and breast cancer risk: a case-control study nested in the EPIC-Varese cohort.Scientific reports · 2017Article
- Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective.Current colorectal cancer reports · 2016Article
- Longitudinal Patterns of Blood Pressure, Incident Cardiovascular Events, and All-Cause Mortality in Normotensive Diabetic People.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Nothing Boring About Boron.Integrative medicine (Encinitas, Calif.) · 2015Review
- Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study.Journal of the National Cancer Institute · 2015Article
- C-Reactive Protein and Breast Cancer: New Insights from Old Molecule.International journal of breast cancer · 2015Review
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Authors and funding
14 authors.
Funding
Abstract
backgroundC-reactive protein (CRP) has been associated with cancer risk in some prospective studies. However, the associations have not been entirely consistent and have not been evaluated in Chinese females. We conducted a large population-based cohort study to investigate whether elevated levels of CRP at baseline are associated with an increased risk of cancer among Chinese females.
methodsA total of 19,437 women from the Chinese Kailuan Female Cohort were enrolled in the study in July 2006. Levels of high-sensitivity CRP (hsCRP) were tested at baseline for all subjects. Multivariable Cox proportional hazards regression models were used to evaluate the association between levels of hsCRP and risk of all cancers, including breast cancer, lung cancer, colorectal cancer, and other cancers.
resultsBy December 31, 2011, a total of 322 incident cancer cases accrued. Compared with women with lower hsCRP levels (<1 mg/L), women with higher hsCRP (>3 mg/L) had a significantly increased risk of all incident cancers [HR, 1.62; 95% confidence intervals (CI), 1.23-2.14; P(trend) = 0.001] and breast cancer (HR, 1.74; 95% CI, 1.01-2.97; P(trend) = 0.047). The significant association between hsCRP levels and breast cancer risk was apparent among younger women (<50 years; HR, 2.76; 95% CI, 1.18-6.48).
conclusionElevated levels of hsCRP at baseline may be associated with an increased risk of cancer, especially breast cancer, and particularly in younger Chinese women. IMPACT: Our findings provide additional evidence for a role of inflammation in carcinogenesis and suggest that CRP may be a potentially useful biomarker of cancer risk in this population.
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